Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage
OBJECTIVE: The aim of the study was to consider logical basis of serum and cerebrospinal fluid (CSF) S100B measurement in pregnant females to detect any cerebral damage. STUDY DESIGN: CSF and serum samples from 14 pregnant patients (age: 20-34 years) were obtained during spinal anesthetic procedure...
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| Format: | Article |
| Language: | English |
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Medical Network
2009-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/407 |
| _version_ | 1797912592107175936 |
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| author | Nilüfer Çelik Önder Çelik Halis Canpolat Osman Evliyaoğlu Muammer Karakaş |
| author_facet | Nilüfer Çelik Önder Çelik Halis Canpolat Osman Evliyaoğlu Muammer Karakaş |
| author_sort | Nilüfer Çelik |
| collection | DOAJ |
| description | OBJECTIVE: The aim of the study was to consider logical basis of serum and cerebrospinal fluid (CSF) S100B measurement in pregnant females to detect any cerebral damage.
STUDY DESIGN: CSF and serum samples from 14 pregnant patients (age: 20-34 years) were obtained during spinal anesthetic procedure of cesarean section. The serum samples from 9 non-pregnant patients (22–36 years) without an organic brain disease were used as normative data. S-100B levels in serum and CSF samples were measured with electrochemiluminescence immunoassay method. The
CSF and blood serum levels of pregnants and blood serum levels of pregnant and nonpregnant females were compared using Kruskal-Wallis and Mann-Whitney U-tests.
RESULTS: Serum S100B protein levels of pregnant females were significantly higher [0.66±0.06 ng/ml] than those observed in [0.06±0.00 ng/ml] nonpregnant females (p<.0001). There was a significant difference between the S100B protein levels of CSF and blood serum (p<0.05) in pregnant females. However the correlation between these two levels was insignificant (p=0.473). CSF S100B levels of
pregnant subjcets were significantly higher than the serum levels of pregnant and nonpregnant subjects (p<0.0001).
DISCUSSION: These results prove that the maternal serum and CSF S100B protein levels are independently related to each other in pregnancy. |
| first_indexed | 2024-04-10T11:58:22Z |
| format | Article |
| id | doaj.art-85be0b8de7d440408b98f19cf18e08d5 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T11:58:22Z |
| publishDate | 2009-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-85be0b8de7d440408b98f19cf18e08d52023-02-15T16:16:44ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512009-08-01152339Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral DamageNilüfer Çelik0Önder Çelik1Halis Canpolat2Osman Evliyaoğlu3Muammer Karakaş4Beydağı State Hospital Clinical Biochemistry, MalatyaDepartments of Obstetrics and Gynecology, İnönü University School of Medicine, MalatyaDepartments of Anesthesiology, İnönü University School of Medicine, MalatyaBeydağı State Hospital Clinical Biochemistry, MalatyaDepartments of Radiology, İnönü University School of Medicine, MalatyaOBJECTIVE: The aim of the study was to consider logical basis of serum and cerebrospinal fluid (CSF) S100B measurement in pregnant females to detect any cerebral damage. STUDY DESIGN: CSF and serum samples from 14 pregnant patients (age: 20-34 years) were obtained during spinal anesthetic procedure of cesarean section. The serum samples from 9 non-pregnant patients (22–36 years) without an organic brain disease were used as normative data. S-100B levels in serum and CSF samples were measured with electrochemiluminescence immunoassay method. The CSF and blood serum levels of pregnants and blood serum levels of pregnant and nonpregnant females were compared using Kruskal-Wallis and Mann-Whitney U-tests. RESULTS: Serum S100B protein levels of pregnant females were significantly higher [0.66±0.06 ng/ml] than those observed in [0.06±0.00 ng/ml] nonpregnant females (p<.0001). There was a significant difference between the S100B protein levels of CSF and blood serum (p<0.05) in pregnant females. However the correlation between these two levels was insignificant (p=0.473). CSF S100B levels of pregnant subjcets were significantly higher than the serum levels of pregnant and nonpregnant subjects (p<0.0001). DISCUSSION: These results prove that the maternal serum and CSF S100B protein levels are independently related to each other in pregnancy.http://gorm.com.tr/index.php/GORM/article/view/407S-100B, Pregnancy, Cerebrospinal fluid, Serum |
| spellingShingle | Nilüfer Çelik Önder Çelik Halis Canpolat Osman Evliyaoğlu Muammer Karakaş Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage Gynecology Obstetrics & Reproductive Medicine S-100B, Pregnancy, Cerebrospinal fluid, Serum |
| title | Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage |
| title_full | Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage |
| title_fullStr | Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage |
| title_full_unstemmed | Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage |
| title_short | Logical Basis of Cerebrospinal Fluid and Serum S-100B Protein Measurement in Pregnant Women to Detect any Possible Cerebral Damage |
| title_sort | logical basis of cerebrospinal fluid and serum s 100b protein measurement in pregnant women to detect any possible cerebral damage |
| topic | S-100B, Pregnancy, Cerebrospinal fluid, Serum |
| url | http://gorm.com.tr/index.php/GORM/article/view/407 |
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