Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
Johannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-06-01
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| Series: | Hepatic Medicine: Evidence and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/transarterial-chemoembolization-with-drug-eluting-beads-versus-convent-peer-reviewed-article-HMER |
| _version_ | 1818425941601288192 |
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| author | Baur J Ritter CO Germer CT Klein I Kickuth R Steger U |
| author_facet | Baur J Ritter CO Germer CT Klein I Kickuth R Steger U |
| author_sort | Baur J |
| collection | DOAJ |
| description | Johannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE). Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever. Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1% vs 12.5%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference. Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE. Keywords: transarterial chemoembolization, hepatocellular carcinoma, drug-eluting beads |
| first_indexed | 2024-12-14T14:21:56Z |
| format | Article |
| id | doaj.art-85c18b34a0df48ff8106e3f8cb215412 |
| institution | Directory Open Access Journal |
| issn | 1179-1535 |
| language | English |
| last_indexed | 2024-12-14T14:21:56Z |
| publishDate | 2016-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Hepatic Medicine: Evidence and Research |
| spelling | doaj.art-85c18b34a0df48ff8106e3f8cb2154122022-12-21T22:58:02ZengDove Medical PressHepatic Medicine: Evidence and Research1179-15352016-06-012016Issue 1697427508Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinomaBaur JRitter COGermer CTKlein IKickuth RSteger UJohannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE). Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever. Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1% vs 12.5%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference. Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE. Keywords: transarterial chemoembolization, hepatocellular carcinoma, drug-eluting beadshttps://www.dovepress.com/transarterial-chemoembolization-with-drug-eluting-beads-versus-convent-peer-reviewed-article-HMERTransarterial ChemoembolisationHepatocellular CarcinomaDrug Eluting Beads |
| spellingShingle | Baur J Ritter CO Germer CT Klein I Kickuth R Steger U Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma Hepatic Medicine: Evidence and Research Transarterial Chemoembolisation Hepatocellular Carcinoma Drug Eluting Beads |
| title | Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| title_full | Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| title_fullStr | Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| title_full_unstemmed | Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| title_short | Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| title_sort | transarterial chemoembolization with drug eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma |
| topic | Transarterial Chemoembolisation Hepatocellular Carcinoma Drug Eluting Beads |
| url | https://www.dovepress.com/transarterial-chemoembolization-with-drug-eluting-beads-versus-convent-peer-reviewed-article-HMER |
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