Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

The precise characterization and quantification of oxidative protein damage is a significant challenge due to the low abundance, large variety, and heterogeneity of modifications. Mass spectrometry (MS)-based techniques at the peptide level (proteomics) provide a detailed but limited picture due to...

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Bibliographic Details
Main Authors: Luke F. Gamon, Chaorui Guo, Jianfei He, Per Hägglund, Clare L. Hawkins, Michael J. Davies
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Protein oxidation
Post-translational modifications
LC-MS
Hypochlorous acid
Peroxynitrite
Chlorination
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720305802

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