Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo)
ObjectiveSubthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1231883/full |
| _version_ | 1797265545056223232 |
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| author | Wenbin Shen Xiaoxiao Wang Qin Li Qingguo Ding Hongqiang Zhang Zheng Qian Zhixin Sun Xingyu Chen Jun Zhang Mengqi Zhao Lina Huang Wei Xing |
| author_facet | Wenbin Shen Xiaoxiao Wang Qin Li Qingguo Ding Hongqiang Zhang Zheng Qian Zhixin Sun Xingyu Chen Jun Zhang Mengqi Zhao Lina Huang Wei Xing |
| author_sort | Wenbin Shen |
| collection | DOAJ |
| description | ObjectiveSubthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobic exercise on resting-state brain function.MethodsA total of 78 subjects, aged between 18 and 48 years, (StD group, n = 44; healthy control (HC) group, n = 34) engaged in moderate-intensity aerobic exercise 3–4 times per week for 8 weeks. Resting-state brain function and structural images were acquired before and after the exercise intervention. The ReHo method was employed to analyze abnormal changes in regional brain function, and a correlation analysis was performed using the Patient Health Questionnaire-9 (PHQ-9) and Self-Rating Anxiety Scale (SAS) scores.ResultsThe principal observation reveals synchronous abnormalities in the right anterior cingulate gyrus of the brain in StD subjects compared to HCs at baseline, with these differences dissipating after the implementation of aerobic exercise. After completing the aerobic exercise program, the StD group exhibited a difference in the right middle cingulate gyrus, while the left supplementary motor area (SMA) was altered in the HC group.ConclusionDisparities in neural synchronization are evident between HCs and StD subjects, and the implementation of aerobic exercise intervention can effectively mitigate these distinctions, leading to a significant reduction in depressive symptoms among StD subjects. The primary mechanism of StD symptoms may involve the inhibition of the anterior cingulate gyrus, while the effects of aerobic exercise may be related to the modulation of neural synchronization of emotional reflexes. The discovery of these fMRI evidence findings may offer novel strategies for early detection and intervention in cases of StD. |
| first_indexed | 2024-04-25T00:46:30Z |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-25T00:46:30Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-85c254f1505f4a81b7226ddea49e0f9e2024-03-12T04:52:11ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-03-011810.3389/fnins.2024.12318831231883Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo)Wenbin Shen0Xiaoxiao Wang1Qin Li2Qingguo Ding3Hongqiang Zhang4Zheng Qian5Zhixin Sun6Xingyu Chen7Jun Zhang8Mengqi Zhao9Lina Huang10Wei Xing11Department of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaSchool of Foreign Studies, China University of Petroleum, Qingdao, Shandong, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Psychiatry, Changshu Third People's Hospital, Changshu, Jiangsu, ChinaSchool of Psychology, Zhejiang Normal University, Jinhua, Zhejiang, ChinaDepartment of Radiology, The Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, ChinaDepartment of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaObjectiveSubthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobic exercise on resting-state brain function.MethodsA total of 78 subjects, aged between 18 and 48 years, (StD group, n = 44; healthy control (HC) group, n = 34) engaged in moderate-intensity aerobic exercise 3–4 times per week for 8 weeks. Resting-state brain function and structural images were acquired before and after the exercise intervention. The ReHo method was employed to analyze abnormal changes in regional brain function, and a correlation analysis was performed using the Patient Health Questionnaire-9 (PHQ-9) and Self-Rating Anxiety Scale (SAS) scores.ResultsThe principal observation reveals synchronous abnormalities in the right anterior cingulate gyrus of the brain in StD subjects compared to HCs at baseline, with these differences dissipating after the implementation of aerobic exercise. After completing the aerobic exercise program, the StD group exhibited a difference in the right middle cingulate gyrus, while the left supplementary motor area (SMA) was altered in the HC group.ConclusionDisparities in neural synchronization are evident between HCs and StD subjects, and the implementation of aerobic exercise intervention can effectively mitigate these distinctions, leading to a significant reduction in depressive symptoms among StD subjects. The primary mechanism of StD symptoms may involve the inhibition of the anterior cingulate gyrus, while the effects of aerobic exercise may be related to the modulation of neural synchronization of emotional reflexes. The discovery of these fMRI evidence findings may offer novel strategies for early detection and intervention in cases of StD.https://www.frontiersin.org/articles/10.3389/fnins.2024.1231883/fullsubthreshold depressionaerobic exerciseneuroimagingpreventionresting-stateregional homogeneity |
| spellingShingle | Wenbin Shen Xiaoxiao Wang Qin Li Qingguo Ding Hongqiang Zhang Zheng Qian Zhixin Sun Xingyu Chen Jun Zhang Mengqi Zhao Lina Huang Wei Xing Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) Frontiers in Neuroscience subthreshold depression aerobic exercise neuroimaging prevention resting-state regional homogeneity |
| title | Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) |
| title_full | Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) |
| title_fullStr | Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) |
| title_full_unstemmed | Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) |
| title_short | Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) |
| title_sort | research on adults with subthreshold depression after aerobic exercise a resting state fmri study based on regional homogeneity reho |
| topic | subthreshold depression aerobic exercise neuroimaging prevention resting-state regional homogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1231883/full |
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