HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in brea...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2018-10-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310&tlng=en |
| _version_ | 1818720033841348608 |
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| author | Iris Rabinovich Lúcia de Noronha Ana Paula M. Sebastião Rubens S. Lima Cícero A. Urban Eduardo Schunemann Jr. Selene Elífio-Esposito Cleverton C. Spautz Andréa N. Moreno-Amaral |
| author_facet | Iris Rabinovich Lúcia de Noronha Ana Paula M. Sebastião Rubens S. Lima Cícero A. Urban Eduardo Schunemann Jr. Selene Elífio-Esposito Cleverton C. Spautz Andréa N. Moreno-Amaral |
| author_sort | Iris Rabinovich |
| collection | DOAJ |
| description | ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis. |
| first_indexed | 2024-12-17T20:16:24Z |
| format | Article |
| id | doaj.art-85c27220ffe94fed901b6895fa547d3d |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-17T20:16:24Z |
| publishDate | 2018-10-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-85c27220ffe94fed901b6895fa547d3d2022-12-21T21:34:06ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742018-10-0154531031810.5935/1676-2444.20180052HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-Iris RabinovichLúcia de NoronhaAna Paula M. SebastiãoRubens S. LimaCícero A. UrbanEduardo Schunemann Jr.Selene Elífio-EspositoCleverton C. SpautzAndréa N. Moreno-AmaralABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310&tlng=enbreast neoplasmsneoplastic stem cellsCD44 antigensCD24 antigensbreast ductal carcinoma |
| spellingShingle | Iris Rabinovich Lúcia de Noronha Ana Paula M. Sebastião Rubens S. Lima Cícero A. Urban Eduardo Schunemann Jr. Selene Elífio-Esposito Cleverton C. Spautz Andréa N. Moreno-Amaral HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- Jornal Brasileiro de Patologia e Medicina Laboratorial breast neoplasms neoplastic stem cells CD44 antigens CD24 antigens breast ductal carcinoma |
| title | HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
| title_full | HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
| title_fullStr | HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
| title_full_unstemmed | HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
| title_short | HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
| title_sort | her2 expressing breast tumors are associated with breast cancer stem cell phenotype cd44 cd24 |
| topic | breast neoplasms neoplastic stem cells CD44 antigens CD24 antigens breast ductal carcinoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310&tlng=en |
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