HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-

HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-

ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in brea...

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Bibliographic Details
Main Authors: Iris Rabinovich, Lúcia de Noronha, Ana Paula M. Sebastião, Rubens S. Lima, Cícero A. Urban, Eduardo Schunemann Jr., Selene Elífio-Esposito, Cleverton C. Spautz, Andréa N. Moreno-Amaral
Format: Article
Language:English
Published: Sociedade Brasileira de Patologia Clínica 2018-10-01
Series:Jornal Brasileiro de Patologia e Medicina Laboratorial
Subjects:
breast neoplasms
neoplastic stem cells
CD44 antigens
CD24 antigens
breast ductal carcinoma
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310&tlng=en

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