The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors
Leukemic stem cells (LSCs) drive chemoresistance and relapse in acute myeloid leukemia. Here, the authors show that the splicing factor RBM17 supports LSCs through avoiding nonsense-mediated decay of pro-leukaemic factors such as the translation initiation factor EIF4A2.
Bibliographic Details
| Main Authors: |
Lina Liu,
Ana Vujovic,
Nandan P. Deshpande,
Shashank Sathe,
Govardhan Anande,
He Tian Tony Chen,
Joshua Xu,
Mark D. Minden,
Gene W. Yeo,
Ashwin Unnikrishnan,
Kristin J. Hope,
Yu Lu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31155-0
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