Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention
Acute kidney injury (AKI) is characterized by a rapid deterioration of kidney function, representing a global healthcare concern. In addition, AKI survivors frequently develop chronic kidney disease (CKD), contributing to a substantial proportion of disease burden globally. Yet, over the past 30 yea...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/20/11093 |
| _version_ | 1797514385903583232 |
|---|---|
| author | Letizia De Chiara Carolina Conte Giulia Antonelli Elena Lazzeri |
| author_facet | Letizia De Chiara Carolina Conte Giulia Antonelli Elena Lazzeri |
| author_sort | Letizia De Chiara |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is characterized by a rapid deterioration of kidney function, representing a global healthcare concern. In addition, AKI survivors frequently develop chronic kidney disease (CKD), contributing to a substantial proportion of disease burden globally. Yet, over the past 30 years, the burden of CKD has not declined to the same extent as many other important non-communicable diseases, implying a substantial deficit in the understanding of the disease progression. The assumption that the kidney response to AKI is based on a high proliferative potential of proximal tubular cells (PTC) caused a critical confounding factor, which has led to a limited development of strategies to prevent AKI and halt progression toward CKD. In this review, we discuss the latest findings on multiple mechanisms of response related to cell cycle behavior of PTC upon AKI, with a specific focus on their biological relevance. Collectively, we aim to (1) provide a new perspective on interpreting cell cycle progression of PTC in response to damage and (2) discuss how this knowledge can be used to choose the right therapeutic window of treatment for preserving kidney function while avoiding CKD progression. |
| first_indexed | 2024-03-10T06:30:52Z |
| format | Article |
| id | doaj.art-85c3c56febae4f0e893531216cd050d7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:30:52Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-85c3c56febae4f0e893531216cd050d72023-11-22T18:33:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201109310.3390/ijms222011093Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD PreventionLetizia De Chiara0Carolina Conte1Giulia Antonelli2Elena Lazzeri3Department of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, 50139 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, 50139 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, 50139 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences Mario Serio, University of Florence, 50139 Florence, ItalyAcute kidney injury (AKI) is characterized by a rapid deterioration of kidney function, representing a global healthcare concern. In addition, AKI survivors frequently develop chronic kidney disease (CKD), contributing to a substantial proportion of disease burden globally. Yet, over the past 30 years, the burden of CKD has not declined to the same extent as many other important non-communicable diseases, implying a substantial deficit in the understanding of the disease progression. The assumption that the kidney response to AKI is based on a high proliferative potential of proximal tubular cells (PTC) caused a critical confounding factor, which has led to a limited development of strategies to prevent AKI and halt progression toward CKD. In this review, we discuss the latest findings on multiple mechanisms of response related to cell cycle behavior of PTC upon AKI, with a specific focus on their biological relevance. Collectively, we aim to (1) provide a new perspective on interpreting cell cycle progression of PTC in response to damage and (2) discuss how this knowledge can be used to choose the right therapeutic window of treatment for preserving kidney function while avoiding CKD progression.https://www.mdpi.com/1422-0067/22/20/11093acute kidney injurychronic kidney diseasemitotic cell cyclecell cycle arrestalternative cell cyclepolyploidy |
| spellingShingle | Letizia De Chiara Carolina Conte Giulia Antonelli Elena Lazzeri Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention International Journal of Molecular Sciences acute kidney injury chronic kidney disease mitotic cell cycle cell cycle arrest alternative cell cycle polyploidy |
| title | Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention |
| title_full | Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention |
| title_fullStr | Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention |
| title_full_unstemmed | Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention |
| title_short | Tubular Cell Cycle Response upon AKI: Revising Old and New Paradigms to Identify Novel Targets for CKD Prevention |
| title_sort | tubular cell cycle response upon aki revising old and new paradigms to identify novel targets for ckd prevention |
| topic | acute kidney injury chronic kidney disease mitotic cell cycle cell cycle arrest alternative cell cycle polyploidy |
| url | https://www.mdpi.com/1422-0067/22/20/11093 |
| work_keys_str_mv | AT letiziadechiara tubularcellcycleresponseuponakirevisingoldandnewparadigmstoidentifynoveltargetsforckdprevention AT carolinaconte tubularcellcycleresponseuponakirevisingoldandnewparadigmstoidentifynoveltargetsforckdprevention AT giuliaantonelli tubularcellcycleresponseuponakirevisingoldandnewparadigmstoidentifynoveltargetsforckdprevention AT elenalazzeri tubularcellcycleresponseuponakirevisingoldandnewparadigmstoidentifynoveltargetsforckdprevention |