Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson’s disease, and sequence variations are associated with the sporadic form of the disease. LRRK2 phosphorylates a subset of RAB proteins implicated in secretory and recycling trafficking pathways, including RA...

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Bibliographic Details
Main Authors: Pilar Rivero-Ríos, Maria Romo-Lozano, Belén Fernández, Elena Fdez, Sabine Hilfiker
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
Parkinson’s disease
LRRK2
RAB10
RAB29
endolysosome
Golgi
Online Access:https://www.mdpi.com/2073-4409/9/7/1719

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