Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis
Background: A high detection rate of diabetes among dental visitors has been reported recently. This systematic review aimed to evaluate the association between periodontitis and glycated hemoglobin (HbA1c) levels among non-diabetic individuals. Methods: The EMBASE, MEDLINE, Web of Science, Cochrane...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/19/2649 |
| _version_ | 1797575827065405440 |
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| author | Dan Zhao Yangyang Sun Xin Li Xiaoxiao Wang Lijie Lu Chen Li Yaping Pan Songlin Wang |
| author_facet | Dan Zhao Yangyang Sun Xin Li Xiaoxiao Wang Lijie Lu Chen Li Yaping Pan Songlin Wang |
| author_sort | Dan Zhao |
| collection | DOAJ |
| description | Background: A high detection rate of diabetes among dental visitors has been reported recently. This systematic review aimed to evaluate the association between periodontitis and glycated hemoglobin (HbA1c) levels among non-diabetic individuals. Methods: The EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed, and Open GREY databases were searched, and observational studies published until 1st June 2023 were identified. A methodological quality assessment was conducted based on the original and modified versions of the Newcastle–Ottawa scale. Cohort, case–control, and cross-sectional studies that performed clinical periodontal examinations and measured HbA1c levels in non-diabetic adults were included. A meta-analysis was conducted to estimate the weighted mean difference (WMD) between individuals with and without periodontitis. Results: In total, 29 case–control and 5 cross-sectional studies were selected from 2583 potentially eligible articles. Among them, sixteen case–control and three cross-sectional studies with moderate to high quality were selected for the meta-analyses. The HbA1c levels in periodontitis patients were significantly higher than those in individuals with healthy periodontal conditions (WMD = 0.16; <i>p</i> < 0.001) among the non-diabetic populations. Conclusions: This study reveals a significant association between periodontitis and HbA1c levels in non-diabetic populations. Thus, HbA1c screening may be recommended to detect potential hyperglycemia in non-diabetic periodontitis patients. |
| first_indexed | 2024-03-10T21:44:48Z |
| format | Article |
| id | doaj.art-85c4382ad71d40019ea5efcbb6162419 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T21:44:48Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-85c4382ad71d40019ea5efcbb61624192023-11-19T14:25:19ZengMDPI AGHealthcare2227-90322023-09-011119264910.3390/healthcare11192649Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-AnalysisDan Zhao0Yangyang Sun1Xin Li2Xiaoxiao Wang3Lijie Lu4Chen Li5Yaping Pan6Songlin Wang7Department of Implant Dentistry, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, ChinaSchool of Public Health, National Institute for Data Science in Health and Medicine, Capital Medical University, Beijing 100069, ChinaDepartment of Oral Implantology and Prosthodontics, Shenzhen Stomatology Hospital Affiliated to Shenzhen University, Shenzhen 518001, ChinaDepartment of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, ChinaDepartment of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, ChinaDepartment of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, ChinaBeijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaBackground: A high detection rate of diabetes among dental visitors has been reported recently. This systematic review aimed to evaluate the association between periodontitis and glycated hemoglobin (HbA1c) levels among non-diabetic individuals. Methods: The EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed, and Open GREY databases were searched, and observational studies published until 1st June 2023 were identified. A methodological quality assessment was conducted based on the original and modified versions of the Newcastle–Ottawa scale. Cohort, case–control, and cross-sectional studies that performed clinical periodontal examinations and measured HbA1c levels in non-diabetic adults were included. A meta-analysis was conducted to estimate the weighted mean difference (WMD) between individuals with and without periodontitis. Results: In total, 29 case–control and 5 cross-sectional studies were selected from 2583 potentially eligible articles. Among them, sixteen case–control and three cross-sectional studies with moderate to high quality were selected for the meta-analyses. The HbA1c levels in periodontitis patients were significantly higher than those in individuals with healthy periodontal conditions (WMD = 0.16; <i>p</i> < 0.001) among the non-diabetic populations. Conclusions: This study reveals a significant association between periodontitis and HbA1c levels in non-diabetic populations. Thus, HbA1c screening may be recommended to detect potential hyperglycemia in non-diabetic periodontitis patients.https://www.mdpi.com/2227-9032/11/19/2649HbA1cearly diagnosisperiodontitishyperglycemiadiabetes mellitussystematic review |
| spellingShingle | Dan Zhao Yangyang Sun Xin Li Xiaoxiao Wang Lijie Lu Chen Li Yaping Pan Songlin Wang Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis Healthcare HbA1c early diagnosis periodontitis hyperglycemia diabetes mellitus systematic review |
| title | Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis |
| title_full | Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis |
| title_short | Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis |
| title_sort | association between periodontitis and hba1c levels in non diabetic patients a systematic review and meta analysis |
| topic | HbA1c early diagnosis periodontitis hyperglycemia diabetes mellitus systematic review |
| url | https://www.mdpi.com/2227-9032/11/19/2649 |
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