Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a result, it remains unclear in many cases if the rep...

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Bibliographic Details
Main Authors: Xiaohui Yuan, Tuong Chi Ta, Min Lin, Jane R Evans, Yinchen Dong, Eugene Bolotin, Mark A Sherman, Barry M Forman, Frances M Sladek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680617?pdf=render

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