In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina
Background: The <i>Ziziphus mistol</i> fruit (vulgar name mistol) is used in northwestern Argentina in traditional food and beverage preparations and popular medicines for liver and respiratory disorders. Aims: The aim of this research was to evaluate the hypoglycemic and anti-inflammato...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/14/2125 |
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| author | María Eugenia Orqueda Sebastian Torres Iris Catiana Zampini María Inés Isla |
| author_facet | María Eugenia Orqueda Sebastian Torres Iris Catiana Zampini María Inés Isla |
| author_sort | María Eugenia Orqueda |
| collection | DOAJ |
| description | Background: The <i>Ziziphus mistol</i> fruit (vulgar name mistol) is used in northwestern Argentina in traditional food and beverage preparations and popular medicines for liver and respiratory disorders. Aims: The aim of this research was to evaluate the hypoglycemic and anti-inflammatory activity in pulp powders and sub-products (skin and seeds) of mistol fruit, along with their toxicity. Methods: Powders from mistol seeds, pulp, and skin were obtained. Antioxidant capacity and inhibitory activity against key enzymes involved in metabolic syndrome were determined by in vitro assays. Results: The mistol powders obtained from the different fruit parts reduced glucose bioaccessibility. Before and after simulated gastroduodenal digestion, the polyphenol-enriched extracts (PEE) obtained from mistol powders increased glucose uptake by yeast cells and inhibited the pivotal enzymes of the inflammatory pathway (cyclooxygenase-2, lipooxygenase-1, and phospholipase A<sub>2</sub>). The analyzed mistol powders did not show acute toxicity or genotoxicity in model organisms and cell cultures. Conclusions: These results evince the potentiality of both the pulp from <i>Z. mistol</i> fruits and residual biomass (seeds and skin) to obtain biofunctional powders to use as supplements for metabolic disorders associated with chronic diseases. |
| first_indexed | 2024-03-09T10:19:20Z |
| format | Article |
| id | doaj.art-85c4ffa6064945029a7c47f18ae112c0 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T10:19:20Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-85c4ffa6064945029a7c47f18ae112c02023-12-01T22:10:09ZengMDPI AGFoods2304-81582022-07-011114212510.3390/foods11142125In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from ArgentinaMaría Eugenia Orqueda0Sebastian Torres1Iris Catiana Zampini2María Inés Isla3Natural Products Research Laboratory (LIPRON), Institute of Bioprospecting and Plant Physiology (INBIOFIV-CONICET-UNT), San Lorenzo 1469, San Miguel de Tucumán 4000, ArgentinaNatural Products Research Laboratory (LIPRON), Institute of Bioprospecting and Plant Physiology (INBIOFIV-CONICET-UNT), San Lorenzo 1469, San Miguel de Tucumán 4000, ArgentinaNatural Products Research Laboratory (LIPRON), Institute of Bioprospecting and Plant Physiology (INBIOFIV-CONICET-UNT), San Lorenzo 1469, San Miguel de Tucumán 4000, ArgentinaNatural Products Research Laboratory (LIPRON), Institute of Bioprospecting and Plant Physiology (INBIOFIV-CONICET-UNT), San Lorenzo 1469, San Miguel de Tucumán 4000, ArgentinaBackground: The <i>Ziziphus mistol</i> fruit (vulgar name mistol) is used in northwestern Argentina in traditional food and beverage preparations and popular medicines for liver and respiratory disorders. Aims: The aim of this research was to evaluate the hypoglycemic and anti-inflammatory activity in pulp powders and sub-products (skin and seeds) of mistol fruit, along with their toxicity. Methods: Powders from mistol seeds, pulp, and skin were obtained. Antioxidant capacity and inhibitory activity against key enzymes involved in metabolic syndrome were determined by in vitro assays. Results: The mistol powders obtained from the different fruit parts reduced glucose bioaccessibility. Before and after simulated gastroduodenal digestion, the polyphenol-enriched extracts (PEE) obtained from mistol powders increased glucose uptake by yeast cells and inhibited the pivotal enzymes of the inflammatory pathway (cyclooxygenase-2, lipooxygenase-1, and phospholipase A<sub>2</sub>). The analyzed mistol powders did not show acute toxicity or genotoxicity in model organisms and cell cultures. Conclusions: These results evince the potentiality of both the pulp from <i>Z. mistol</i> fruits and residual biomass (seeds and skin) to obtain biofunctional powders to use as supplements for metabolic disorders associated with chronic diseases.https://www.mdpi.com/2304-8158/11/14/2125<i>Ziziphus mistol</i>hypoglycemic effectanti-inflammatory effectpulp powdersby-products powders |
| spellingShingle | María Eugenia Orqueda Sebastian Torres Iris Catiana Zampini María Inés Isla In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina Foods <i>Ziziphus mistol</i> hypoglycemic effect anti-inflammatory effect pulp powders by-products powders |
| title | In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina |
| title_full | In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina |
| title_fullStr | In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina |
| title_full_unstemmed | In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina |
| title_short | In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of <i>Ziziphus mistol</i> from Argentina |
| title_sort | in vitro hypoglycemic and anti inflammatory potential and toxicity of powders from pulp and by products of i ziziphus mistol i from argentina |
| topic | <i>Ziziphus mistol</i> hypoglycemic effect anti-inflammatory effect pulp powders by-products powders |
| url | https://www.mdpi.com/2304-8158/11/14/2125 |
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