Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

IntroductionSurvival among people with HIV-associated cryptococcal meningitis (CM) remains low, particularly among women, despite the currently optimal use of antifungal drugs. Cryptococcus dissemination into the central nervous system [brain, spinal cord, and cerebrospinal fluid (CSF)] elicits the...

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Bibliographic Details
Main Authors: Samuel Okurut, David R. Boulware, Elizabeth Okafor, Joshua Rhein, Henry Kajumbula, Bernard S. Bagaya, Freddie Bwanga, Joseph O. Olobo, Yukari C. Manabe, David B. Meya, Edward N. Janoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
cryptococcal meningitis
cerebrospinal fluid (CSF)
neuroimmune responses
chemokine CXCL10
cytokine IL-15
CCL11/Eotaxin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275443/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275443/full

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