Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

IntroductionSurvival among people with HIV-associated cryptococcal meningitis (CM) remains low, particularly among women, despite the currently optimal use of antifungal drugs. Cryptococcus dissemination into the central nervous system [brain, spinal cord, and cerebrospinal fluid (CSF)] elicits the...

Full description

Bibliographic Details
Main Authors:	Samuel Okurut, David R. Boulware, Elizabeth Okafor, Joshua Rhein, Henry Kajumbula, Bernard S. Bagaya, Freddie Bwanga, Joseph O. Olobo, Yukari C. Manabe, David B. Meya, Edward N. Janoff
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Immunology
Subjects:	cryptococcal meningitis cerebrospinal fluid (CSF) neuroimmune responses chemokine CXCL10 cytokine IL-15 CCL11/Eotaxin
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275443/full

Similar Items

HIV-Associated Cryptococcal Immune Reconstitution Inflammatory Syndrome Is Associated with Aberrant T Cell Function and Increased Cytokine Responses
by: David B. Meya, et al.
Published: (2019-05-01)

Longitudinal Changes in CD4<sup>+</sup>, CD8<sup>+</sup> T Cell Phenotype and Activation Marker Expression Following Antiretroviral Therapy Initiation among Patients with Cryptococcal Meningitis
by: Alice Bayiyana, et al.
Published: (2019-07-01)

Persistently elevated intracranial pressure in cryptococcal meningitis– 76 therapeutic lumbar punctures
by: Samuel Jjunju, et al.
Published: (2023-06-01)

Sterile Cerebrospinal Fluid Culture at Cryptococcal Meningitis Diagnosis Is Associated with High Mortality
by: Caleb P Skipper, et al.
Published: (2022-12-01)

Symptomatic Cryptococcal Meningitis with Negative Serum and Cerebrospinal Fluid Cryptococcal Antigen Tests
by: Nanfuka V, et al.
Published: (2021-09-01)

Gastrointestinal cryptococcoma – Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?
by: Abdu K. Musubire, et al.
Published: (2015-06-01)

Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: a prospective cohort study
by: Cynthia Ahimbisibwe, et al.
Published: (2019-06-01)

Fungal CNS Infections in Africa: The Neuroimmunology of Cryptococcal Meningitis
by: Sally H. Mohamed, et al.
Published: (2022-04-01)

Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis
by: Irina Vlasova-St Louis, et al.
Published: (2021-04-01)

Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis
by: Edward Mpoza, et al.
Published: (2018-03-01)

Cytomegalovirus viremia as a risk factor for mortality in HIV-associated cryptococcal and tuberculous meningitis
by: Caleb P. Skipper, et al.
Published: (2022-09-01)

Tuberculosis preventive therapy (TPT) to prevent tuberculosis co-infection among adults with HIV-associated cryptococcal meningitis: A clinician’s perspective
by: John Kasibante, et al.
Published: (2020-08-01)

Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts
by: Martha P. Montgomery, et al.
Published: (2017-06-01)

Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast
by: David R. Boulware, et al.
Published: (2014-01-01)

Pathways to care with HIV-associated cryptococcal meningitis in Botswana and Uganda: Findings from a qualitative methods study
by: David S. Lawrence, et al.
Published: (2023-12-01)

Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.
by: David R Boulware, et al.
Published: (2010-12-01)

Neuroimmune regulation in the pancreas
by: Xiaofan Ding, et al.
Published: (2024-03-01)

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation
by: Reuben Kiggundu, et al.
Published: (2014-07-01)

Cryptococcal pneumonia and meningitis in a renal transplant recipient with a false negative serum cryptococcal antigen due to postzone phenomenon
by: Chelsea Ware, et al.
Published: (2023-01-01)

Implications of Neuroimmunity in Alzheimer’s Disease: A Review
by: Katriel Lee
Published: (2017-10-01)

Distal jejunal obstruction due to Cryptococcus neoformans and rifampicin-resistant Mycobacterium tuberculosis co-infection: A case report
by: John Kasibante, et al.
Published: (2022-12-01)

Impact of community engagement and social support on the outcomes of HIV-related meningitis clinical trials in a resource-limited setting
by: Richard Kwizera, et al.
Published: (2020-08-01)

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders
by: Mariya Ivanovska, et al.
Published: (2020-09-01)

Computerised tomography findings in HIV-associated cryptococcal meningoencephalitis at a tertiary hospital in Pretoria
by: Nausheen Khan, et al.
Published: (2017-11-01)

Underlying Cryptococcal Diseases and the Correlation With Serum Cryptococcal Antigen Titers in Hospitalized HIV-Infected Patients Screened Positive for Cryptococcal Antigenemia
by: Miaomiao Xu, et al.
Published: (2020-04-01)

Long term 5-year survival of persons with cryptococcal meningitis or asymptomatic subclinical antigenemia in Uganda.
by: Elissa K Butler, et al.
Published: (2012-01-01)

Neuroimmune communication in allergic rhinitis
by: Yi Zhou, et al.
Published: (2023-12-01)

Neuroimmune Regulation of Surgery-Associated Metastases
by: Michael R. Shurin, et al.
Published: (2021-02-01)

Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways
by: Patrícia Lavandoski, et al.
Published: (2023-10-01)

The Role of CCL24 in Systemic Sclerosis
by: Hilit Levy, et al.
Published: (2023-07-01)

Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders
by: Antonio L. Teixeira, et al.
Published: (2018-06-01)

Preemptive Therapy for Cryptococcal Meningitis: A Valid Strategy for Latin America?
by: José E. Vidal
Published: (2016-05-01)

Interactions of neuroimmune signaling and glutamate plasticity in addiction
by: Cassandra D. Gipson, et al.
Published: (2021-02-01)

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration
by: Aaron D. Talsma, et al.
Published: (2022-07-01)

Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
by: Daniel B. Lowy, et al.
Published: (2021-04-01)

Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
by: Jose E. Vidal, et al.
Published: (2013-06-01)

Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
by: Jose E. Vidal, et al.

The Role of Heparan Sulfate in CCL26-Induced Eosinophil Chemotaxis
by: Alexandra Pum, et al.
Published: (2022-06-01)

CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age
by: Simone Lieschke, et al.
Published: (2019-12-01)

Case Report: Cryptococcal eosinophilic meningitis in a patient with Hodgkin lymphoma
by: Fang Zhang, et al.
Published: (2022-09-01)