A method for campus-wide SARS-CoV-2 surveillance at a large public university.
The systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of infectious disease on college campuses. Faced with a paucity of testing in the beginning of the COVID-19 pandemic, many universities developed molecular diagnostic la...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0261230 |
| _version_ | 1811296444305375232 |
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| author | Terren Chang Jolene M Draper Anouk Van den Bout Ellen Kephart Hannah Maul-Newby Yvonne Vasquez Jason Woodbury Savanna Randi Martina Pedersen Maeve Nave Scott La Natalie Gallagher Molly M McCabe Namrita Dhillon Isabel Bjork Michael Luttrell Frank Dang John B MacMillan Ralph Green Elizabeth Miller Auston M Kilpatrick Olena Vaske Michael D Stone Jeremy R Sanford |
| author_facet | Terren Chang Jolene M Draper Anouk Van den Bout Ellen Kephart Hannah Maul-Newby Yvonne Vasquez Jason Woodbury Savanna Randi Martina Pedersen Maeve Nave Scott La Natalie Gallagher Molly M McCabe Namrita Dhillon Isabel Bjork Michael Luttrell Frank Dang John B MacMillan Ralph Green Elizabeth Miller Auston M Kilpatrick Olena Vaske Michael D Stone Jeremy R Sanford |
| author_sort | Terren Chang |
| collection | DOAJ |
| description | The systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of infectious disease on college campuses. Faced with a paucity of testing in the beginning of the COVID-19 pandemic, many universities developed molecular diagnostic laboratories focused on SARS-CoV-2 diagnostic testing on campus and in their broader communities. We established the UC Santa Cruz Molecular Diagnostic Lab in early April 2020 and began testing clinical samples just five weeks later. Using a clinically-validated laboratory developed test (LDT) that avoided supply chain constraints, an automated sample pooling and processing workflow, and a custom laboratory information management system (LIMS), we expanded testing from a handful of clinical samples per day to thousands per day with the testing capacity to screen our entire campus population twice per week. In this report we describe the technical, logistical, and regulatory processes that enabled our pop-up lab to scale testing and reporting capacity to thousands of tests per day. |
| first_indexed | 2024-04-13T05:48:33Z |
| format | Article |
| id | doaj.art-85c72b49ccae48659fd9bbeb29d47838 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T05:48:33Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-85c72b49ccae48659fd9bbeb29d478382022-12-22T02:59:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026123010.1371/journal.pone.0261230A method for campus-wide SARS-CoV-2 surveillance at a large public university.Terren ChangJolene M DraperAnouk Van den BoutEllen KephartHannah Maul-NewbyYvonne VasquezJason WoodburySavanna RandiMartina PedersenMaeve NaveScott LaNatalie GallagherMolly M McCabeNamrita DhillonIsabel BjorkMichael LuttrellFrank DangJohn B MacMillanRalph GreenElizabeth MillerAuston M KilpatrickOlena VaskeMichael D StoneJeremy R SanfordThe systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of infectious disease on college campuses. Faced with a paucity of testing in the beginning of the COVID-19 pandemic, many universities developed molecular diagnostic laboratories focused on SARS-CoV-2 diagnostic testing on campus and in their broader communities. We established the UC Santa Cruz Molecular Diagnostic Lab in early April 2020 and began testing clinical samples just five weeks later. Using a clinically-validated laboratory developed test (LDT) that avoided supply chain constraints, an automated sample pooling and processing workflow, and a custom laboratory information management system (LIMS), we expanded testing from a handful of clinical samples per day to thousands per day with the testing capacity to screen our entire campus population twice per week. In this report we describe the technical, logistical, and regulatory processes that enabled our pop-up lab to scale testing and reporting capacity to thousands of tests per day.https://doi.org/10.1371/journal.pone.0261230 |
| spellingShingle | Terren Chang Jolene M Draper Anouk Van den Bout Ellen Kephart Hannah Maul-Newby Yvonne Vasquez Jason Woodbury Savanna Randi Martina Pedersen Maeve Nave Scott La Natalie Gallagher Molly M McCabe Namrita Dhillon Isabel Bjork Michael Luttrell Frank Dang John B MacMillan Ralph Green Elizabeth Miller Auston M Kilpatrick Olena Vaske Michael D Stone Jeremy R Sanford A method for campus-wide SARS-CoV-2 surveillance at a large public university. PLoS ONE |
| title | A method for campus-wide SARS-CoV-2 surveillance at a large public university. |
| title_full | A method for campus-wide SARS-CoV-2 surveillance at a large public university. |
| title_fullStr | A method for campus-wide SARS-CoV-2 surveillance at a large public university. |
| title_full_unstemmed | A method for campus-wide SARS-CoV-2 surveillance at a large public university. |
| title_short | A method for campus-wide SARS-CoV-2 surveillance at a large public university. |
| title_sort | method for campus wide sars cov 2 surveillance at a large public university |
| url | https://doi.org/10.1371/journal.pone.0261230 |
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