Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People
Background and AimsSoluble Klotho (S-Klotho) is a protein that has anti-aging properties. Dietary inflammation index (DII) is closely related to various age-related diseases. However, whether DII is related to S-Klotho plasma levels is still controversial. It was the goal of this study to examine th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.853332/full |
| _version_ | 1817985927719419904 |
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| author | Teng-Chi Ma Jing Zhou Chen-Xi Wang Min Fang Feng Gao |
| author_facet | Teng-Chi Ma Jing Zhou Chen-Xi Wang Min Fang Feng Gao |
| author_sort | Teng-Chi Ma |
| collection | DOAJ |
| description | Background and AimsSoluble Klotho (S-Klotho) is a protein that has anti-aging properties. Dietary inflammation index (DII) is closely related to various age-related diseases. However, whether DII is related to S-Klotho plasma levels is still controversial. It was the goal of this study to examine the link between DII and S-Klotho in middle-aged and elderly people.MethodsBetween 2007 and 2016, five NHANES cycles were conducted, with 12,315 middle-aged and elderly (aged 40–79) participants having S-Klotho tests and submitting dietary recall data. The inflammatory potential of a diet was determined using the DII. To determine the plasma levels of S-Klotho, we employed a solid-phase sandwich enzyme-linked immunosorbent assay (ELISA).ResultsThere was a negative correlation between DII and S-Klotho plasma levels. In the threshold effect analysis model, the breakpoint was DII=1.3, and the negative correlation was more obvious when DII < 1.3 (β = −10.6, p = 0.001). When DII > 1.3, the correlation disappeared (p = 0.355). There may be a threshold saturation effect.ConclusionIn middle-aged and older individuals, there is a negative connection between the pro-inflammatory dietary pattern as evaluated by DII and the plasma level of S-Klotho. Given the rationale for the findings and the study's limitations, the fundamental mechanisms generating inflammation warrant additional exploration. |
| first_indexed | 2024-04-14T00:03:09Z |
| format | Article |
| id | doaj.art-85c7979918fe48b1baace119ed7e5465 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-14T00:03:09Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-85c7979918fe48b1baace119ed7e54652022-12-22T02:23:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.853332853332Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly PeopleTeng-Chi MaJing ZhouChen-Xi WangMin FangFeng GaoBackground and AimsSoluble Klotho (S-Klotho) is a protein that has anti-aging properties. Dietary inflammation index (DII) is closely related to various age-related diseases. However, whether DII is related to S-Klotho plasma levels is still controversial. It was the goal of this study to examine the link between DII and S-Klotho in middle-aged and elderly people.MethodsBetween 2007 and 2016, five NHANES cycles were conducted, with 12,315 middle-aged and elderly (aged 40–79) participants having S-Klotho tests and submitting dietary recall data. The inflammatory potential of a diet was determined using the DII. To determine the plasma levels of S-Klotho, we employed a solid-phase sandwich enzyme-linked immunosorbent assay (ELISA).ResultsThere was a negative correlation between DII and S-Klotho plasma levels. In the threshold effect analysis model, the breakpoint was DII=1.3, and the negative correlation was more obvious when DII < 1.3 (β = −10.6, p = 0.001). When DII > 1.3, the correlation disappeared (p = 0.355). There may be a threshold saturation effect.ConclusionIn middle-aged and older individuals, there is a negative connection between the pro-inflammatory dietary pattern as evaluated by DII and the plasma level of S-Klotho. Given the rationale for the findings and the study's limitations, the fundamental mechanisms generating inflammation warrant additional exploration.https://www.frontiersin.org/articles/10.3389/fnut.2022.853332/fullagingdietary inflammatory indexKlothoinflammationdiet |
| spellingShingle | Teng-Chi Ma Jing Zhou Chen-Xi Wang Min Fang Feng Gao Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People Frontiers in Nutrition aging dietary inflammatory index Klotho inflammation diet |
| title | Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People |
| title_full | Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People |
| title_fullStr | Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People |
| title_full_unstemmed | Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People |
| title_short | Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People |
| title_sort | association between dietary inflammatory index and s klotho plasma levels in middle aged and elderly people |
| topic | aging dietary inflammatory index Klotho inflammation diet |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.853332/full |
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