Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
Abstract Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-022-00421-y |
| _version_ | 1817984069011505152 |
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| author | Xiangbo Xu Yuting Wu Shixue Xu Yue Yin Walter Ageno Valerio De Stefano Qingchun Zhao Xingshun Qi |
| author_facet | Xiangbo Xu Yuting Wu Shixue Xu Yue Yin Walter Ageno Valerio De Stefano Qingchun Zhao Xingshun Qi |
| author_sort | Xiangbo Xu |
| collection | DOAJ |
| description | Abstract Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods. |
| first_indexed | 2024-04-13T23:40:55Z |
| format | Article |
| id | doaj.art-85c84636d1fb4ea893de94657d3efb56 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-13T23:40:55Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-85c84636d1fb4ea893de94657d3efb562022-12-22T02:24:31ZengBMCThrombosis Journal1477-95602022-10-0120111710.1186/s12959-022-00421-yClinical significance of neutrophil extracellular traps biomarkers in thrombosisXiangbo Xu0Yuting Wu1Shixue Xu2Yue Yin3Walter Ageno4Valerio De Stefano5Qingchun Zhao6Xingshun Qi7Department of Gastroenterology, General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University)Department of Life Science and Biochemistry, Shenyang Pharmaceutical UniversityDepartment of Gastroenterology, General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University)Department of Medicine and Surgery, University of InsubriaDepartment of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico A. Gemelli IRCCS, Section of HematologyDepartment of Life Science and Biochemistry, Shenyang Pharmaceutical UniversityDepartment of Gastroenterology, General Hospital of Northern Theater Command (the Teaching School of Shenyang Pharmaceutical University)Abstract Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods.https://doi.org/10.1186/s12959-022-00421-yNeutrophilNeutrophil extracellular trapsThrombosisCitrullinated histonesMyeloperoxidase |
| spellingShingle | Xiangbo Xu Yuting Wu Shixue Xu Yue Yin Walter Ageno Valerio De Stefano Qingchun Zhao Xingshun Qi Clinical significance of neutrophil extracellular traps biomarkers in thrombosis Thrombosis Journal Neutrophil Neutrophil extracellular traps Thrombosis Citrullinated histones Myeloperoxidase |
| title | Clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| title_full | Clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| title_fullStr | Clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| title_full_unstemmed | Clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| title_short | Clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| title_sort | clinical significance of neutrophil extracellular traps biomarkers in thrombosis |
| topic | Neutrophil Neutrophil extracellular traps Thrombosis Citrullinated histones Myeloperoxidase |
| url | https://doi.org/10.1186/s12959-022-00421-y |
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