Lithiated porous silicon nanowires stimulate periodontal regeneration
Abstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approache...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44581-5 |
| _version_ | 1827382076232433664 |
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| author | Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S’Ari Davide Alessandro Martella Mark Isaacs Ermei Mäkilä Cong Wang Evelin Moldenhauer Paul Clarke Alessandra Pinna Xuechen Zhang Salman A. Mustfa Valeria Caprettini Alexander P. Morrell Eileen Gentleman Delia S. Brauer Owen Addison Xuehui Zhang Mads Bergholt Khuloud Al-Jamal Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini |
| author_facet | Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S’Ari Davide Alessandro Martella Mark Isaacs Ermei Mäkilä Cong Wang Evelin Moldenhauer Paul Clarke Alessandra Pinna Xuechen Zhang Salman A. Mustfa Valeria Caprettini Alexander P. Morrell Eileen Gentleman Delia S. Brauer Owen Addison Xuehui Zhang Mads Bergholt Khuloud Al-Jamal Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini |
| author_sort | Martti Kaasalainen |
| collection | DOAJ |
| description | Abstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect. |
| first_indexed | 2024-03-08T14:14:17Z |
| format | Article |
| id | doaj.art-85c8a505ba6a428da2da5b7913bb668b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T14:14:17Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-85c8a505ba6a428da2da5b7913bb668b2024-01-14T12:29:39ZengNature PortfolioNature Communications2041-17232024-01-0115111610.1038/s41467-023-44581-5Lithiated porous silicon nanowires stimulate periodontal regenerationMartti Kaasalainen0Ran Zhang1Priya Vashisth2Anahid Ahmadi Birjandi3Mark S’Ari4Davide Alessandro Martella5Mark Isaacs6Ermei Mäkilä7Cong Wang8Evelin Moldenhauer9Paul Clarke10Alessandra Pinna11Xuechen Zhang12Salman A. Mustfa13Valeria Caprettini14Alexander P. Morrell15Eileen Gentleman16Delia S. Brauer17Owen Addison18Xuehui Zhang19Mads Bergholt20Khuloud Al-Jamal21Ana Angelova Volponi22Jarno Salonen23Nicole Hondow24Paul Sharpe25Ciro Chiappini26Centre for Craniofacial and Regenerative Biology, King’s College LondonDepartment of Oral Pathology, Peking University School and Hospital of StomatologyCentre for Craniofacial and Regenerative Biology, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonSchool of Chemical and Process Engineering, University of LeedsCentre for Craniofacial and Regenerative Biology, King’s College LondonDepartment of Chemistry, University College LondonDepartment of Physics and Astronomy, University of TurkuCentre for Craniofacial and Regenerative Biology, King’s College LondonPostnova Analytics GmbHPostnova Analytics GmbHDepartment of Materials, Imperial College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonCentre for Oral Clinical & Translational Sciences, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonOtto Schott Institute of Materials Research, Friedrich Schiller University JenaCentre for Oral Clinical & Translational Sciences, King’s College LondonDepartment of Dental Materials & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of StomatologyCentre for Craniofacial and Regenerative Biology, King’s College LondonInstitute of Pharmaceutical Science, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonDepartment of Physics and Astronomy, University of TurkuSchool of Chemical and Process Engineering, University of LeedsCentre for Craniofacial and Regenerative Biology, King’s College LondonCentre for Craniofacial and Regenerative Biology, King’s College LondonAbstract Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.https://doi.org/10.1038/s41467-023-44581-5 |
| spellingShingle | Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S’Ari Davide Alessandro Martella Mark Isaacs Ermei Mäkilä Cong Wang Evelin Moldenhauer Paul Clarke Alessandra Pinna Xuechen Zhang Salman A. Mustfa Valeria Caprettini Alexander P. Morrell Eileen Gentleman Delia S. Brauer Owen Addison Xuehui Zhang Mads Bergholt Khuloud Al-Jamal Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini Lithiated porous silicon nanowires stimulate periodontal regeneration Nature Communications |
| title | Lithiated porous silicon nanowires stimulate periodontal regeneration |
| title_full | Lithiated porous silicon nanowires stimulate periodontal regeneration |
| title_fullStr | Lithiated porous silicon nanowires stimulate periodontal regeneration |
| title_full_unstemmed | Lithiated porous silicon nanowires stimulate periodontal regeneration |
| title_short | Lithiated porous silicon nanowires stimulate periodontal regeneration |
| title_sort | lithiated porous silicon nanowires stimulate periodontal regeneration |
| url | https://doi.org/10.1038/s41467-023-44581-5 |
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