A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity.

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity.

Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional Class XIV myosin; TgMLC1, a myosin light chain;...

Full description

Bibliographic Details
Main Authors: Aoife T Heaslip, Jacqueline M Leung, Kimberly L Carey, Federica Catti, David M Warshaw, Nicholas J Westwood, Bryan A Ballif, Gary E Ward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2800044?pdf=render

Similar Items

Similar Items