Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo
Bladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low; thus, there remains a need to improve prognosis by identifying novel targets. Kin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.12768 |
| _version_ | 1797374919180288000 |
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| author | Qingchun Zhou Juan Yu Qingyou Zheng Tao Wu Ziliang Ji Yumin Zhuo |
| author_facet | Qingchun Zhou Juan Yu Qingyou Zheng Tao Wu Ziliang Ji Yumin Zhuo |
| author_sort | Qingchun Zhou |
| collection | DOAJ |
| description | Bladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low; thus, there remains a need to improve prognosis by identifying novel targets. Kinesins (kinesin superfamily proteins) are a series of microtubule‐based motor proteins that mediate various types of cellular processes. Kinesin family member 3A (KIF3A) is critical for cytoplasm separation in mitosis, and it has been reported to be misexpressed in multiple types of cancer. However, its effects on the progression and development of bladder cancer remain unclear. Herein, we report that KIF3A is highly expressed in human bladder cancer. We identified a significant correlation between KIF3A and clinical features, including clinical stage (P = 0.047), pathological tumor status (P = 0.045), lymph node status (P = 0.041) and metastasis (P = 0.035). KIF3A expression was also correlated with poor prognosis of patients with bladder cancer. Our results further indicated that KIF3A ablation resulted in cell cycle arrest; blocked the proliferation, migration and invasion of bladder cancer cells in vitro; and restrained tumor growth in mice in a microtubule‐dependent manner. In summary, our findings suggest that KIF3A is a potential therapeutic target for bladder cancer. |
| first_indexed | 2024-03-08T19:12:42Z |
| format | Article |
| id | doaj.art-85cfe60dc6d84b9eaf08faae67a71b2f |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-08T19:12:42Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-85cfe60dc6d84b9eaf08faae67a71b2f2023-12-27T09:30:57ZengWileyFEBS Open Bio2211-54632021-05-011151487149610.1002/2211-5463.12768Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivoQingchun Zhou0Juan Yu1Qingyou Zheng2Tao Wu3Ziliang Ji4Yumin Zhuo5Department of Urology First Affiliated Hospital Jinan University Guangzhou City ChinaDepartment of Medical Imaging Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University ChinaDepartment of Urology Shenzhen Hospital Southern Medical University Shenzhen City ChinaDepartment of Urology Shenzhen Hospital Southern Medical University Shenzhen City ChinaDepartment of Urology Shenzhen Hospital Southern Medical University Shenzhen City ChinaDepartment of Urology First Affiliated Hospital Jinan University Guangzhou City ChinaBladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low; thus, there remains a need to improve prognosis by identifying novel targets. Kinesins (kinesin superfamily proteins) are a series of microtubule‐based motor proteins that mediate various types of cellular processes. Kinesin family member 3A (KIF3A) is critical for cytoplasm separation in mitosis, and it has been reported to be misexpressed in multiple types of cancer. However, its effects on the progression and development of bladder cancer remain unclear. Herein, we report that KIF3A is highly expressed in human bladder cancer. We identified a significant correlation between KIF3A and clinical features, including clinical stage (P = 0.047), pathological tumor status (P = 0.045), lymph node status (P = 0.041) and metastasis (P = 0.035). KIF3A expression was also correlated with poor prognosis of patients with bladder cancer. Our results further indicated that KIF3A ablation resulted in cell cycle arrest; blocked the proliferation, migration and invasion of bladder cancer cells in vitro; and restrained tumor growth in mice in a microtubule‐dependent manner. In summary, our findings suggest that KIF3A is a potential therapeutic target for bladder cancer.https://doi.org/10.1002/2211-5463.12768bladder cancerKIF3Akinesinmigrationproliferationtherapeutic target |
| spellingShingle | Qingchun Zhou Juan Yu Qingyou Zheng Tao Wu Ziliang Ji Yumin Zhuo Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo FEBS Open Bio bladder cancer KIF3A kinesin migration proliferation therapeutic target |
| title | Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo |
| title_full | Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo |
| title_fullStr | Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo |
| title_full_unstemmed | Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo |
| title_short | Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo |
| title_sort | retracted kinesin family member 3a stimulates cell proliferation migration and invasion of bladder cancer cells in vitro and in vivo |
| topic | bladder cancer KIF3A kinesin migration proliferation therapeutic target |
| url | https://doi.org/10.1002/2211-5463.12768 |
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