Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

Background/Aims: Interleukin (IL)-1β plays an essential role in the pathophysiology of osteoarthritis (OA). Cytokine response modifier A (CrmA) can prevent the generation of active IL-1β. This study aimed to explore the chondroprotective effects of hyaluronic acid-chitosan nanoparticles containing p...

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Bibliographic Details
Main Authors: Pang-hu Zhou, Bo Qiu, Rong-hui Deng, Hua-jie Li, Xiong-feng Xu, Xi-fu Shang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cytokine response modifer A
Hyaluronic acid
Chitosan
Nanoparticles
Gene delivery
Osteoarthritis
Online Access:https://www.karger.com/Article/FullText/490217

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