Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall
<p>Abstract</p> <p>Background</p> <p>Uterine or endocervical biopsies that contain endometrioid adenocarcinoma with widespread squamous metaplasia are usually of endometrial origin. The presence of squamous metaplasia is said to be helpful in distinguishing endocervical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-10-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/2/1/40 |
| _version_ | 1819026111662653440 |
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| author | Murdoch John Sen Chandan Hirschowitz Lynn |
| author_facet | Murdoch John Sen Chandan Hirschowitz Lynn |
| author_sort | Murdoch John |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Uterine or endocervical biopsies that contain endometrioid adenocarcinoma with widespread squamous metaplasia are usually of endometrial origin. The presence of squamous metaplasia is said to be helpful in distinguishing endocervical from endometrial adenocarcinomas in small biopsy samples.</p> <p>Case presentation</p> <p>A 51-year-old woman presented with post-coital and post-menopausal bleeding. Biopsy of a friable lesion in the proximal endocervical canal revealed an endocervical adenocarcinoma of endometrioid type with widespread squamous metaplasia. The latter feature initially raised the possible diagnosis of a primary endometrial adenocarcinoma. However, immunohistochemical marker studies indicated a diagnosis of primary endocervical adenocarcinoma of endometrioid type and this was confirmed at hysterectomy.</p> <p>Conclusion</p> <p>Squamous differentiation is not well documented in endocervical adenocarcinomas of endometrioid type and, when widespread, may represent a diagnostic pitfall for pathologists. Interpretation of small biopsies from the endocervical canal on the basis of morphology alone may lead to misdiagnosis and inappropriate surgical management.</p> |
| first_indexed | 2024-12-21T05:21:23Z |
| format | Article |
| id | doaj.art-85d390308d63409db741083e38de4b14 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-21T05:21:23Z |
| publishDate | 2007-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-85d390308d63409db741083e38de4b142022-12-21T19:14:47ZengBMCDiagnostic Pathology1746-15962007-10-01214010.1186/1746-1596-2-40Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfallMurdoch JohnSen ChandanHirschowitz Lynn<p>Abstract</p> <p>Background</p> <p>Uterine or endocervical biopsies that contain endometrioid adenocarcinoma with widespread squamous metaplasia are usually of endometrial origin. The presence of squamous metaplasia is said to be helpful in distinguishing endocervical from endometrial adenocarcinomas in small biopsy samples.</p> <p>Case presentation</p> <p>A 51-year-old woman presented with post-coital and post-menopausal bleeding. Biopsy of a friable lesion in the proximal endocervical canal revealed an endocervical adenocarcinoma of endometrioid type with widespread squamous metaplasia. The latter feature initially raised the possible diagnosis of a primary endometrial adenocarcinoma. However, immunohistochemical marker studies indicated a diagnosis of primary endocervical adenocarcinoma of endometrioid type and this was confirmed at hysterectomy.</p> <p>Conclusion</p> <p>Squamous differentiation is not well documented in endocervical adenocarcinomas of endometrioid type and, when widespread, may represent a diagnostic pitfall for pathologists. Interpretation of small biopsies from the endocervical canal on the basis of morphology alone may lead to misdiagnosis and inappropriate surgical management.</p>http://www.diagnosticpathology.org/content/2/1/40 |
| spellingShingle | Murdoch John Sen Chandan Hirschowitz Lynn Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall Diagnostic Pathology |
| title | Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall |
| title_full | Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall |
| title_fullStr | Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall |
| title_full_unstemmed | Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall |
| title_short | Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall |
| title_sort | primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia a potential diagnostic pitfall |
| url | http://www.diagnosticpathology.org/content/2/1/40 |
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