Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

The breakdown of the endothelial cell (EC) barrier contributes significantly to sepsis mortality. Sphingosine 1-phosphate (S1P) is one of the most effective EC barrier-stabilizing signaling molecules. Stabilization is mainly transduced via the S1P receptor type 1 (S1PR1). Here, we demonstrate that S...

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Bibliographic Details
Main Authors: Jefri Jeya Paul, Cynthia Weigel, Tina Müller, Regine Heller, Sarah Spiegel, Markus H. Gräler
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
S1P receptor
inflammation
S1P transporter
spinster homolog 2
barrier dysfunction
Online Access:https://www.mdpi.com/2073-4409/9/4/928

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