Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.
Obesity is a common finding and a major pathogenetic factor in obstructive sleep apnea (OSA) in adults. To understand the mechanisms behind this, the present study investigated the tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig model. In 4 ve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293907&type=printable |
| _version_ | 1797315857292984320 |
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| author | Daniel F Leotta Daniel Ly Bishoy Galil Jeff Thiel Elliot Willis Niranjan Balu Zi-Jun Liu |
| author_facet | Daniel F Leotta Daniel Ly Bishoy Galil Jeff Thiel Elliot Willis Niranjan Balu Zi-Jun Liu |
| author_sort | Daniel F Leotta |
| collection | DOAJ |
| description | Obesity is a common finding and a major pathogenetic factor in obstructive sleep apnea (OSA) in adults. To understand the mechanisms behind this, the present study investigated the tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig model. In 4 verified obese/OSA and 3 non-obese/non-OSA control minipigs, MRI fat-weighted images, ultrasound elastography (USE), and sleep video-fluoroscopy (SVF) were performed to quantify the fat composition, tissue stiffness, and respiratory kinematics of the tongue base and soft palate during sedated sleep. The results indicated that the fat composition gradually increased from the rostral to caudal tongue base, particularly in the posterior 1/3 of the tongue base, regardless of the presence of obesity and OSA. However, this trend was not seen in the soft palate and pharyngeal wall. The pharyngeal wall presented the highest fat composition as compared with the tongue base and soft palate. Overall, obese OSA minipigs showed stiffer tongue tissue than the controls, particularly in the rostral region of the tongue in obese Yucatan minipigs. The respiratory moving ranges of the soft palate were greater in both dorsal-ventral and rostral-caudal directions and during both respiratory and expiratory phases in OSA obese than control minipigs, and the largest moving ranges were seen in OSA obese Panepinto minipigs. The moving range of the tongue base was significantly smaller. These results suggest more fat infiltration in the caudal region of the tongue base regardless of the presence of obesity and/or OSA. The greater tissue stiffness of the tongue in obese OSA minipigs may result from altered neuromuscular drive. |
| first_indexed | 2024-03-08T03:09:55Z |
| format | Article |
| id | doaj.art-85d7b2e35af449f4bb2bcbeee9f08283 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T03:09:55Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-85d7b2e35af449f4bb2bcbeee9f082832024-02-13T05:34:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011812e029390710.1371/journal.pone.0293907Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig.Daniel F LeottaDaniel LyBishoy GalilJeff ThielElliot WillisNiranjan BaluZi-Jun LiuObesity is a common finding and a major pathogenetic factor in obstructive sleep apnea (OSA) in adults. To understand the mechanisms behind this, the present study investigated the tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig model. In 4 verified obese/OSA and 3 non-obese/non-OSA control minipigs, MRI fat-weighted images, ultrasound elastography (USE), and sleep video-fluoroscopy (SVF) were performed to quantify the fat composition, tissue stiffness, and respiratory kinematics of the tongue base and soft palate during sedated sleep. The results indicated that the fat composition gradually increased from the rostral to caudal tongue base, particularly in the posterior 1/3 of the tongue base, regardless of the presence of obesity and OSA. However, this trend was not seen in the soft palate and pharyngeal wall. The pharyngeal wall presented the highest fat composition as compared with the tongue base and soft palate. Overall, obese OSA minipigs showed stiffer tongue tissue than the controls, particularly in the rostral region of the tongue in obese Yucatan minipigs. The respiratory moving ranges of the soft palate were greater in both dorsal-ventral and rostral-caudal directions and during both respiratory and expiratory phases in OSA obese than control minipigs, and the largest moving ranges were seen in OSA obese Panepinto minipigs. The moving range of the tongue base was significantly smaller. These results suggest more fat infiltration in the caudal region of the tongue base regardless of the presence of obesity and/or OSA. The greater tissue stiffness of the tongue in obese OSA minipigs may result from altered neuromuscular drive.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293907&type=printable |
| spellingShingle | Daniel F Leotta Daniel Ly Bishoy Galil Jeff Thiel Elliot Willis Niranjan Balu Zi-Jun Liu Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. PLoS ONE |
| title | Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. |
| title_full | Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. |
| title_fullStr | Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. |
| title_full_unstemmed | Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. |
| title_short | Tissue properties and respiratory kinematics of the tongue base and soft palate in the obese OSA minipig. |
| title_sort | tissue properties and respiratory kinematics of the tongue base and soft palate in the obese osa minipig |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293907&type=printable |
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