Anti-Tumor Effect of Parasitic Protozoans
The immune system may aberrantly silence when against “altered self”, which consequently may develop into malignancies. With the development of tumor immunology and molecular biology, the deepened understanding of the relationship between parasites and tumors shifts the attitude towards parasitic pa...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/9/8/395 |
| _version_ | 1797432438729736192 |
|---|---|
| author | Haojie Ding Songrui Wu Zi Jin Bin Zheng Yuan Hu Ke He Shaohong Lu Xunhui Zhuo |
| author_facet | Haojie Ding Songrui Wu Zi Jin Bin Zheng Yuan Hu Ke He Shaohong Lu Xunhui Zhuo |
| author_sort | Haojie Ding |
| collection | DOAJ |
| description | The immune system may aberrantly silence when against “altered self”, which consequently may develop into malignancies. With the development of tumor immunology and molecular biology, the deepened understanding of the relationship between parasites and tumors shifts the attitude towards parasitic pathogens from elimination to utilization. In recent years, the antitumor impact implemented by protozoan parasites and the derived products has been confirmed. The immune system is activated and enhanced by some protozoan parasites, thereby inhibiting tumor growth, angiogenesis, and metastasis in many animal models. In this work, we reviewed the available information on the antitumor effect of parasitic infection or induced by parasitic antigen, as well as the involved immune mechanisms that modulate cancer progression. Despite the fact that clinical trials of the protozoan parasites against tumors are limited and the specific mechanisms of the effect on tumors are not totally clear, the use of genetically modified protozoan parasites and derived molecules combined with chemotherapy could be an important element for promoting antitumor treatment in the future. |
| first_indexed | 2024-03-09T10:01:37Z |
| format | Article |
| id | doaj.art-85dae31780b94a1ab21714a2e70aaedf |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T10:01:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-85dae31780b94a1ab21714a2e70aaedf2023-12-01T23:25:23ZengMDPI AGBioengineering2306-53542022-08-019839510.3390/bioengineering9080395Anti-Tumor Effect of Parasitic ProtozoansHaojie Ding0Songrui Wu1Zi Jin2Bin Zheng3Yuan Hu4Ke He5Shaohong Lu6Xunhui Zhuo7School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaKey Laboratory of Parasite and Vector Biology, National Health Commission of People’s Republic of China, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), WHO Collaborating Center for Tropical Diseases, Shanghai 200025, ChinaCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou 311300, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, ChinaThe immune system may aberrantly silence when against “altered self”, which consequently may develop into malignancies. With the development of tumor immunology and molecular biology, the deepened understanding of the relationship between parasites and tumors shifts the attitude towards parasitic pathogens from elimination to utilization. In recent years, the antitumor impact implemented by protozoan parasites and the derived products has been confirmed. The immune system is activated and enhanced by some protozoan parasites, thereby inhibiting tumor growth, angiogenesis, and metastasis in many animal models. In this work, we reviewed the available information on the antitumor effect of parasitic infection or induced by parasitic antigen, as well as the involved immune mechanisms that modulate cancer progression. Despite the fact that clinical trials of the protozoan parasites against tumors are limited and the specific mechanisms of the effect on tumors are not totally clear, the use of genetically modified protozoan parasites and derived molecules combined with chemotherapy could be an important element for promoting antitumor treatment in the future.https://www.mdpi.com/2306-5354/9/8/395anti-tumorprotozoonbiotherapyimmune responsetumor microenvironment |
| spellingShingle | Haojie Ding Songrui Wu Zi Jin Bin Zheng Yuan Hu Ke He Shaohong Lu Xunhui Zhuo Anti-Tumor Effect of Parasitic Protozoans Bioengineering anti-tumor protozoon biotherapy immune response tumor microenvironment |
| title | Anti-Tumor Effect of Parasitic Protozoans |
| title_full | Anti-Tumor Effect of Parasitic Protozoans |
| title_fullStr | Anti-Tumor Effect of Parasitic Protozoans |
| title_full_unstemmed | Anti-Tumor Effect of Parasitic Protozoans |
| title_short | Anti-Tumor Effect of Parasitic Protozoans |
| title_sort | anti tumor effect of parasitic protozoans |
| topic | anti-tumor protozoon biotherapy immune response tumor microenvironment |
| url | https://www.mdpi.com/2306-5354/9/8/395 |
| work_keys_str_mv | AT haojieding antitumoreffectofparasiticprotozoans AT songruiwu antitumoreffectofparasiticprotozoans AT zijin antitumoreffectofparasiticprotozoans AT binzheng antitumoreffectofparasiticprotozoans AT yuanhu antitumoreffectofparasiticprotozoans AT kehe antitumoreffectofparasiticprotozoans AT shaohonglu antitumoreffectofparasiticprotozoans AT xunhuizhuo antitumoreffectofparasiticprotozoans |