2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likenes...

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Bibliographic Details
Main Authors: Afreen Md, Venkanna Muripiti, Shireesha Manturthi, Amarnath Velidandi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Chalcone
Urea
Pyrimidine
Cell-viability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624001218
Description
Summary:Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likeness, drug score. The In- vitro cell viability studies using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX against 4 T1 Celline shows prominent results.
ISSN:2211-7156

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