2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies
Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likenes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624001218 |
| _version_ | 1797262930364858368 |
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| author | Afreen Md Venkanna Muripiti Shireesha Manturthi Amarnath Velidandi |
| author_facet | Afreen Md Venkanna Muripiti Shireesha Manturthi Amarnath Velidandi |
| author_sort | Afreen Md |
| collection | DOAJ |
| description | Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likeness, drug score. The In- vitro cell viability studies using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX against 4 T1 Celline shows prominent results. |
| first_indexed | 2024-04-25T00:04:56Z |
| format | Article |
| id | doaj.art-85db7c531cce44a8bb60f084bdcc1ce9 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-25T00:04:56Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-85db7c531cce44a8bb60f084bdcc1ce92024-03-14T06:14:32ZengElsevierResults in Chemistry2211-71562024-01-0171014252, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies Afreen Md0Venkanna Muripiti1Shireesha Manturthi2Amarnath Velidandi3Department of Chemistry, Chaitanya Deemed to Be University, Hanamakonda, 506001, Telangana State, IndiaDepartment of education, Central university of Kerala, Kasaragod, Kerala, IndiaCellular and Molecular Medicine, University of Ottawa, RGN 2501, 451 Smyth Road, Ontario, Ottawa, ON K1H 8M5, CanadaDepartment of Chemistry, Chaitanya Deemed to Be University, Hanamakonda, 506001, Telangana State, India; Corresponding author.Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likeness, drug score. The In- vitro cell viability studies using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX against 4 T1 Celline shows prominent results.http://www.sciencedirect.com/science/article/pii/S2211715624001218ChalconeUreaPyrimidineCell-viability |
| spellingShingle | Afreen Md Venkanna Muripiti Shireesha Manturthi Amarnath Velidandi 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies Results in Chemistry Chalcone Urea Pyrimidine Cell-viability |
| title | 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies |
| title_full | 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies |
| title_fullStr | 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies |
| title_full_unstemmed | 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies |
| title_short | 2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies |
| title_sort | 2 6 di substituted pyrimidine based scaffolds synthesis in silico and in vitro cell viability studies |
| topic | Chalcone Urea Pyrimidine Cell-viability |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624001218 |
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