Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma
Glioblastoma (GBM) is the most common and aggressive malignant glioma, treatment of which has not improved significantly in many years. This is due to the unique challenges that GBM tumors present when designing and implementing therapies. Recently, immunotherapy in the form of immune checkpoint inh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/8/2759 |
| _version_ | 1797570558981832704 |
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| author | Stephanie Sanders Waldemar Debinski |
| author_facet | Stephanie Sanders Waldemar Debinski |
| author_sort | Stephanie Sanders |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common and aggressive malignant glioma, treatment of which has not improved significantly in many years. This is due to the unique challenges that GBM tumors present when designing and implementing therapies. Recently, immunotherapy in the form of immune checkpoint inhibition (ICI) has revolutionized the treatment of various malignancies. The application of immune checkpoint inhibition in GBM treatment has shown promising preclinical results. Unfortunately, this has met with little to no success in the clinic thus far. In this review, we will discuss the challenges presented by GBM tumors that likely limit the effect of ICI and discuss the approaches being tested to overcome these challenges. |
| first_indexed | 2024-03-10T20:26:15Z |
| format | Article |
| id | doaj.art-85dbffa6982f460c98aba51f1d80f12b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:26:15Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-85dbffa6982f460c98aba51f1d80f12b2023-11-19T21:44:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218275910.3390/ijms21082759Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of GlioblastomaStephanie Sanders0Waldemar Debinski1Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USADepartment of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USAGlioblastoma (GBM) is the most common and aggressive malignant glioma, treatment of which has not improved significantly in many years. This is due to the unique challenges that GBM tumors present when designing and implementing therapies. Recently, immunotherapy in the form of immune checkpoint inhibition (ICI) has revolutionized the treatment of various malignancies. The application of immune checkpoint inhibition in GBM treatment has shown promising preclinical results. Unfortunately, this has met with little to no success in the clinic thus far. In this review, we will discuss the challenges presented by GBM tumors that likely limit the effect of ICI and discuss the approaches being tested to overcome these challenges.https://www.mdpi.com/1422-0067/21/8/2759glioblastomaimmune checkpoint inhibitorsimmunotherapy |
| spellingShingle | Stephanie Sanders Waldemar Debinski Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma International Journal of Molecular Sciences glioblastoma immune checkpoint inhibitors immunotherapy |
| title | Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma |
| title_full | Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma |
| title_fullStr | Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma |
| title_full_unstemmed | Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma |
| title_short | Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma |
| title_sort | challenges to successful implementation of the immune checkpoint inhibitors for treatment of glioblastoma |
| topic | glioblastoma immune checkpoint inhibitors immunotherapy |
| url | https://www.mdpi.com/1422-0067/21/8/2759 |
| work_keys_str_mv | AT stephaniesanders challengestosuccessfulimplementationoftheimmunecheckpointinhibitorsfortreatmentofglioblastoma AT waldemardebinski challengestosuccessfulimplementationoftheimmunecheckpointinhibitorsfortreatmentofglioblastoma |