Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs
Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple roles during the virus lifecycle. Three of the best...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/10/1182 |
| _version_ | 1797550463120310272 |
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| author | Tanel Punga Mahmoud Darweesh Göran Akusjärvi |
| author_facet | Tanel Punga Mahmoud Darweesh Göran Akusjärvi |
| author_sort | Tanel Punga |
| collection | DOAJ |
| description | Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple roles during the virus lifecycle. Three of the best-characterized HAdV sncRNAs; VA RNA, mivaRNA and MLP-TSS-sRNA will be discussed in the present review. Even though VA RNA has been extensively characterized during the last 60 years, this multifunctional molecule continues to surprise us as more of its structural secrets unfold. Likely, the recent developments on mivaRNA and MLP-TSS-sRNA synthesis and function highlight the importance of these sncRNA in virus replication. Collectively, we will summarize the old and new knowledge about these three viral sncRNAs with focus on their synthesis, structure and functions. |
| first_indexed | 2024-03-10T15:29:39Z |
| format | Article |
| id | doaj.art-85dddd33a8cb46d79b76396683f50754 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T15:29:39Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-85dddd33a8cb46d79b76396683f507542023-11-20T17:43:38ZengMDPI AGViruses1999-49152020-10-011210118210.3390/v12101182Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAsTanel Punga0Mahmoud Darweesh1Göran Akusjärvi2Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, SwedenDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, SwedenDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, SwedenHuman adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple roles during the virus lifecycle. Three of the best-characterized HAdV sncRNAs; VA RNA, mivaRNA and MLP-TSS-sRNA will be discussed in the present review. Even though VA RNA has been extensively characterized during the last 60 years, this multifunctional molecule continues to surprise us as more of its structural secrets unfold. Likely, the recent developments on mivaRNA and MLP-TSS-sRNA synthesis and function highlight the importance of these sncRNA in virus replication. Collectively, we will summarize the old and new knowledge about these three viral sncRNAs with focus on their synthesis, structure and functions.https://www.mdpi.com/1999-4915/12/10/1182human adenovirussncRNAVA RNAmivaRNAPKRDicer |
| spellingShingle | Tanel Punga Mahmoud Darweesh Göran Akusjärvi Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs Viruses human adenovirus sncRNA VA RNA mivaRNA PKR Dicer |
| title | Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs |
| title_full | Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs |
| title_fullStr | Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs |
| title_full_unstemmed | Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs |
| title_short | Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs |
| title_sort | synthesis structure and function of human adenovirus small non coding rnas |
| topic | human adenovirus sncRNA VA RNA mivaRNA PKR Dicer |
| url | https://www.mdpi.com/1999-4915/12/10/1182 |
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