PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP

PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP

Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway which initiates the DNA end resection in HR. Ubi...

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Bibliographic Details
Main Authors:	Zhiyu Qiu, Shuailin Hao, Shikai Song, Ruiling Zhang, Tingyu Yan, Zhifang Lu, Hailong Wang, Zongchao Jia, Jimin Zheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	biochemistry cell biology DNA damage DNA double-strand break CtIP PPIL2 PLK1
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.902403/full

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