Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders
Although Huntington’s disease is generally considered to be a neurological disorder, there is mounting evidence that heart malfunction plays an important role in disease progression. This is perhaps not unexpected since both cardiovascular and nervous systems are strongly connected – both developmen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00559/full |
| _version_ | 1819132904252375040 |
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| author | Bethan J. Critchley Bethan J. Critchley Mark Isalan Mark Isalan Michal Mielcarek Michal Mielcarek Michal Mielcarek |
| author_facet | Bethan J. Critchley Bethan J. Critchley Mark Isalan Mark Isalan Michal Mielcarek Michal Mielcarek Michal Mielcarek |
| author_sort | Bethan J. Critchley |
| collection | DOAJ |
| description | Although Huntington’s disease is generally considered to be a neurological disorder, there is mounting evidence that heart malfunction plays an important role in disease progression. This is perhaps not unexpected since both cardiovascular and nervous systems are strongly connected – both developmentally and subsequently in health and disease. This connection occurs through a system of central and peripheral neurons that control cardiovascular performance, while in return the cardiovascular system works as a sensor for the nervous system to react to physiological events. Hence, given their permanent interconnectivity, any pathological events occurring in one system might affect the second. In addition, some pathological signals from Huntington’s disease might occur simultaneously in both the cardiovascular and nervous systems, since mutant huntingtin protein is expressed in both. Here we aim to review the source of HD-related cardiomyopathy in the light of recently published studies, and to identify similarities between HD-related cardiomyopathy and other neuro-cardio disorders. |
| first_indexed | 2024-12-22T09:38:48Z |
| format | Article |
| id | doaj.art-85e038f2d63e499e983bbb384ce121b6 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T09:38:48Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-85e038f2d63e499e983bbb384ce121b62022-12-21T18:30:45ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-05-01910.3389/fphys.2018.00559337975Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative DisordersBethan J. Critchley0Bethan J. Critchley1Mark Isalan2Mark Isalan3Michal Mielcarek4Michal Mielcarek5Michal Mielcarek6Department of Life Sciences, Imperial College London, London, United KingdomImperial College Centre for Synthetic Biology, Imperial College London, London, United KingdomDepartment of Life Sciences, Imperial College London, London, United KingdomImperial College Centre for Synthetic Biology, Imperial College London, London, United KingdomDepartment of Life Sciences, Imperial College London, London, United KingdomImperial College Centre for Synthetic Biology, Imperial College London, London, United KingdomDepartment of Epidemiology of Rare Diseases and Neuroepidemiology, University of Medical Sciences, Poznań, PolandAlthough Huntington’s disease is generally considered to be a neurological disorder, there is mounting evidence that heart malfunction plays an important role in disease progression. This is perhaps not unexpected since both cardiovascular and nervous systems are strongly connected – both developmentally and subsequently in health and disease. This connection occurs through a system of central and peripheral neurons that control cardiovascular performance, while in return the cardiovascular system works as a sensor for the nervous system to react to physiological events. Hence, given their permanent interconnectivity, any pathological events occurring in one system might affect the second. In addition, some pathological signals from Huntington’s disease might occur simultaneously in both the cardiovascular and nervous systems, since mutant huntingtin protein is expressed in both. Here we aim to review the source of HD-related cardiomyopathy in the light of recently published studies, and to identify similarities between HD-related cardiomyopathy and other neuro-cardio disorders.https://www.frontiersin.org/article/10.3389/fphys.2018.00559/fullneuro-cardio disordersHuntington’s diseasecardiomyopathyCNSheart failure |
| spellingShingle | Bethan J. Critchley Bethan J. Critchley Mark Isalan Mark Isalan Michal Mielcarek Michal Mielcarek Michal Mielcarek Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders Frontiers in Physiology neuro-cardio disorders Huntington’s disease cardiomyopathy CNS heart failure |
| title | Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders |
| title_full | Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders |
| title_fullStr | Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders |
| title_full_unstemmed | Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders |
| title_short | Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders |
| title_sort | neuro cardio mechanisms in huntington s disease and other neurodegenerative disorders |
| topic | neuro-cardio disorders Huntington’s disease cardiomyopathy CNS heart failure |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00559/full |
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