Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment
Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day–night cycle of 24 h 40 min for 36 days (days 7...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00575/full |
| _version_ | 1811300008830435328 |
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| author | Ming Yuan Ming Yuan Marc-Antoine Custaud Marc-Antoine Custaud Zi Xu Jingyu Wang Min Yuan Carole Tafforin Loïc Treffel Loïc Treffel Philippe Arbeille Michel Nicolas Claude Gharib Guillemette Gauquelin-Koch Laurent Arnaud Jean-Christophe Lloret Yinghui Li Nastassia Navasiolava |
| author_facet | Ming Yuan Ming Yuan Marc-Antoine Custaud Marc-Antoine Custaud Zi Xu Jingyu Wang Min Yuan Carole Tafforin Loïc Treffel Loïc Treffel Philippe Arbeille Michel Nicolas Claude Gharib Guillemette Gauquelin-Koch Laurent Arnaud Jean-Christophe Lloret Yinghui Li Nastassia Navasiolava |
| author_sort | Ming Yuan |
| collection | DOAJ |
| description | Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day–night cycle of 24 h 40 min for 36 days (days 72–108). Our aim was to study physiological and psychological consequences of this confinement in four healthy volunteers (one female). CELSS platform consisted of six interconnected modules including four greenhouses. Life support systems were controlled automatically. Body composition, fluid compartments, metabolic state, heart, large vessels, endothelial function, and muscle tone were studied using biological, functional, and/or morphological measurements. Behavioral activities were studied by ethological monitoring; psychological state was assessed by questionnaires. Body weight decreased by ∼2 kg mostly due to lean mass loss. Plasma volume and volume-regulating hormones were mostly stable. Carotid intima-media thickness (IMT) increased by 10–15%. Endothelium-dependent vasodilation decreased. Masseter tone increased by 6–14% suggesting stress, whereas paravertebral muscle tone diminished by 10 ± 6%. Behavioral flow reflecting global activity decreased 1.5- to 2-fold after the first month. Psychological questionnaires revealed decrease in hostility and negative emotions but increase in emotional adaptation suggesting boredom and monotony. One subject was clearly different with lower fitness, higher levels of stress and anxiety, and somatic signs as back pain, peak in masseter tone, increased blood cortisol and C-reactive protein. Comparison of CELSS experiment with Mars500 confinement program suggests the need for countermeasures to prevent increased IMT and endothelial deconditioning. Daily activity in greenhouse could act as countermeasure against psycho-physiological deconditioning. |
| first_indexed | 2024-04-13T06:44:50Z |
| format | Article |
| id | doaj.art-85e17f88010941f396ca31c0d3295a16 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T06:44:50Z |
| publishDate | 2019-05-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-85e17f88010941f396ca31c0d3295a162022-12-22T02:57:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-05-011010.3389/fphys.2019.00575453988Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) ExperimentMing Yuan0Ming Yuan1Marc-Antoine Custaud2Marc-Antoine Custaud3Zi Xu4Jingyu Wang5Min Yuan6Carole Tafforin7Loïc Treffel8Loïc Treffel9Philippe Arbeille10Michel Nicolas11Claude Gharib12Guillemette Gauquelin-Koch13Laurent Arnaud14Jean-Christophe Lloret15Yinghui Li16Nastassia Navasiolava17State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, ChinaSpace Institute of Southern China, Shenzhen, ChinaCentre de Recherche Clinique, Centre Hospitalier Universitaire d’Angers, Angers, FranceMitoVasc UMR INSERM 1083-CNRS 6015, Université d’Angers, Angers, FranceSpace Institute of Southern China, Shenzhen, ChinaState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, ChinaState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, ChinaResearch and Study Group in Human and Space Ethology, Ethospace, Toulouse, FranceInstitut Toulousain d’Ostéopathie, Toulouse, FranceCentre de Recherche International en Biomécanique, Lagarde, FranceFaculté de Médecine, Unité de Médecine et Physiologie Spatiales, Centre Hospitalier Universitaire Trousseau de Tours, Tours, FranceLaboratory of Psychology Psy-DREPI (EA 7458), Sport Sciences Department, University Bourgogne Franche-Comté, Dijon, France0Institut NeuroMyogène, Université Claude Bernard Lyon 1, Lyon, France1Centre National d’Etudes Spatiales, Paris, France1Centre National d’Etudes Spatiales, Paris, France1Centre National d’Etudes Spatiales, Paris, FranceState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, ChinaCentre de Recherche Clinique, Centre Hospitalier Universitaire d’Angers, Angers, FranceConfinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day–night cycle of 24 h 40 min for 36 days (days 72–108). Our aim was to study physiological and psychological consequences of this confinement in four healthy volunteers (one female). CELSS platform consisted of six interconnected modules including four greenhouses. Life support systems were controlled automatically. Body composition, fluid compartments, metabolic state, heart, large vessels, endothelial function, and muscle tone were studied using biological, functional, and/or morphological measurements. Behavioral activities were studied by ethological monitoring; psychological state was assessed by questionnaires. Body weight decreased by ∼2 kg mostly due to lean mass loss. Plasma volume and volume-regulating hormones were mostly stable. Carotid intima-media thickness (IMT) increased by 10–15%. Endothelium-dependent vasodilation decreased. Masseter tone increased by 6–14% suggesting stress, whereas paravertebral muscle tone diminished by 10 ± 6%. Behavioral flow reflecting global activity decreased 1.5- to 2-fold after the first month. Psychological questionnaires revealed decrease in hostility and negative emotions but increase in emotional adaptation suggesting boredom and monotony. One subject was clearly different with lower fitness, higher levels of stress and anxiety, and somatic signs as back pain, peak in masseter tone, increased blood cortisol and C-reactive protein. Comparison of CELSS experiment with Mars500 confinement program suggests the need for countermeasures to prevent increased IMT and endothelial deconditioning. Daily activity in greenhouse could act as countermeasure against psycho-physiological deconditioning.https://www.frontiersin.org/article/10.3389/fphys.2019.00575/fullspaceflight analogCELSSMars missionchronic stressadaptationethological monitoring |
| spellingShingle | Ming Yuan Ming Yuan Marc-Antoine Custaud Marc-Antoine Custaud Zi Xu Jingyu Wang Min Yuan Carole Tafforin Loïc Treffel Loïc Treffel Philippe Arbeille Michel Nicolas Claude Gharib Guillemette Gauquelin-Koch Laurent Arnaud Jean-Christophe Lloret Yinghui Li Nastassia Navasiolava Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment Frontiers in Physiology spaceflight analog CELSS Mars mission chronic stress adaptation ethological monitoring |
| title | Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment |
| title_full | Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment |
| title_fullStr | Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment |
| title_full_unstemmed | Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment |
| title_short | Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment |
| title_sort | multi system adaptation to confinement during the 180 day controlled ecological life support system celss experiment |
| topic | spaceflight analog CELSS Mars mission chronic stress adaptation ethological monitoring |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00575/full |
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