Exosomes in hepatocellular carcinoma: a new horizon
Abstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver the...
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Format: | Article |
Language: | English |
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BMC
2019-01-01
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Series: | Cell Communication and Signaling |
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Online Access: | http://link.springer.com/article/10.1186/s12964-018-0315-1 |
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author | Rui Chen Xin Xu Yuquan Tao Zijun Qian Yongchun Yu |
author_facet | Rui Chen Xin Xu Yuquan Tao Zijun Qian Yongchun Yu |
author_sort | Rui Chen |
collection | DOAJ |
description | Abstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Circulating exosomes can be used as noninvasive biomarkers for early diagnosis, moreover as drug delivery vehicles, provide new insights into the treatment of HCC. |
first_indexed | 2024-12-13T08:26:58Z |
format | Article |
id | doaj.art-85e353327af04ffcb3531c6c0af8a1e0 |
institution | Directory Open Access Journal |
issn | 1478-811X |
language | English |
last_indexed | 2024-12-13T08:26:58Z |
publishDate | 2019-01-01 |
publisher | BMC |
record_format | Article |
series | Cell Communication and Signaling |
spelling | doaj.art-85e353327af04ffcb3531c6c0af8a1e02022-12-21T23:53:52ZengBMCCell Communication and Signaling1478-811X2019-01-0117111110.1186/s12964-018-0315-1Exosomes in hepatocellular carcinoma: a new horizonRui Chen0Xin Xu1Yuquan Tao2Zijun Qian3Yongchun Yu4Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineAbstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Circulating exosomes can be used as noninvasive biomarkers for early diagnosis, moreover as drug delivery vehicles, provide new insights into the treatment of HCC.http://link.springer.com/article/10.1186/s12964-018-0315-1Hepatocellular carcinomaExosomesBiomarkersTherapy |
spellingShingle | Rui Chen Xin Xu Yuquan Tao Zijun Qian Yongchun Yu Exosomes in hepatocellular carcinoma: a new horizon Cell Communication and Signaling Hepatocellular carcinoma Exosomes Biomarkers Therapy |
title | Exosomes in hepatocellular carcinoma: a new horizon |
title_full | Exosomes in hepatocellular carcinoma: a new horizon |
title_fullStr | Exosomes in hepatocellular carcinoma: a new horizon |
title_full_unstemmed | Exosomes in hepatocellular carcinoma: a new horizon |
title_short | Exosomes in hepatocellular carcinoma: a new horizon |
title_sort | exosomes in hepatocellular carcinoma a new horizon |
topic | Hepatocellular carcinoma Exosomes Biomarkers Therapy |
url | http://link.springer.com/article/10.1186/s12964-018-0315-1 |
work_keys_str_mv | AT ruichen exosomesinhepatocellularcarcinomaanewhorizon AT xinxu exosomesinhepatocellularcarcinomaanewhorizon AT yuquantao exosomesinhepatocellularcarcinomaanewhorizon AT zijunqian exosomesinhepatocellularcarcinomaanewhorizon AT yongchunyu exosomesinhepatocellularcarcinomaanewhorizon |