Exosomes in hepatocellular carcinoma: a new horizon

Abstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver the...

Full description

Bibliographic Details
Main Authors: Rui Chen, Xin Xu, Yuquan Tao, Zijun Qian, Yongchun Yu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cell Communication and Signaling
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12964-018-0315-1
_version_ 1818313011851427840
author Rui Chen
Xin Xu
Yuquan Tao
Zijun Qian
Yongchun Yu
author_facet Rui Chen
Xin Xu
Yuquan Tao
Zijun Qian
Yongchun Yu
author_sort Rui Chen
collection DOAJ
description Abstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Circulating exosomes can be used as noninvasive biomarkers for early diagnosis, moreover as drug delivery vehicles, provide new insights into the treatment of HCC.
first_indexed 2024-12-13T08:26:58Z
format Article
id doaj.art-85e353327af04ffcb3531c6c0af8a1e0
institution Directory Open Access Journal
issn 1478-811X
language English
last_indexed 2024-12-13T08:26:58Z
publishDate 2019-01-01
publisher BMC
record_format Article
series Cell Communication and Signaling
spelling doaj.art-85e353327af04ffcb3531c6c0af8a1e02022-12-21T23:53:52ZengBMCCell Communication and Signaling1478-811X2019-01-0117111110.1186/s12964-018-0315-1Exosomes in hepatocellular carcinoma: a new horizonRui Chen0Xin Xu1Yuquan Tao2Zijun Qian3Yongchun Yu4Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineAbstract Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Circulating exosomes can be used as noninvasive biomarkers for early diagnosis, moreover as drug delivery vehicles, provide new insights into the treatment of HCC.http://link.springer.com/article/10.1186/s12964-018-0315-1Hepatocellular carcinomaExosomesBiomarkersTherapy
spellingShingle Rui Chen
Xin Xu
Yuquan Tao
Zijun Qian
Yongchun Yu
Exosomes in hepatocellular carcinoma: a new horizon
Cell Communication and Signaling
Hepatocellular carcinoma
Exosomes
Biomarkers
Therapy
title Exosomes in hepatocellular carcinoma: a new horizon
title_full Exosomes in hepatocellular carcinoma: a new horizon
title_fullStr Exosomes in hepatocellular carcinoma: a new horizon
title_full_unstemmed Exosomes in hepatocellular carcinoma: a new horizon
title_short Exosomes in hepatocellular carcinoma: a new horizon
title_sort exosomes in hepatocellular carcinoma a new horizon
topic Hepatocellular carcinoma
Exosomes
Biomarkers
Therapy
url http://link.springer.com/article/10.1186/s12964-018-0315-1
work_keys_str_mv AT ruichen exosomesinhepatocellularcarcinomaanewhorizon
AT xinxu exosomesinhepatocellularcarcinomaanewhorizon
AT yuquantao exosomesinhepatocellularcarcinomaanewhorizon
AT zijunqian exosomesinhepatocellularcarcinomaanewhorizon
AT yongchunyu exosomesinhepatocellularcarcinomaanewhorizon