Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial.
Key features of virtual reality (VR) that impact the effectiveness of pain reduction remain unknown. We hypothesized that specific features of the VR experience significantly impact VR's effectiveness in reducing pain during pediatric burn dressing care. Our randomized controlled trial included...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Digital Health |
| Online Access: | https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000440&type=printable |
| _version_ | 1797326162671697920 |
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| author | Soumil Jain Megan Armstrong John Luna Rajan K Thakkar Renata Fabia Jonathan I Groner Dana Noffsinger Ai Ni Eric Nelson Henry Xiang |
| author_facet | Soumil Jain Megan Armstrong John Luna Rajan K Thakkar Renata Fabia Jonathan I Groner Dana Noffsinger Ai Ni Eric Nelson Henry Xiang |
| author_sort | Soumil Jain |
| collection | DOAJ |
| description | Key features of virtual reality (VR) that impact the effectiveness of pain reduction remain unknown. We hypothesized that specific features of the VR experience significantly impact VR's effectiveness in reducing pain during pediatric burn dressing care. Our randomized controlled trial included children 6 to 17 years (inclusive) who were treated in the outpatient clinic of an American Burn Association-verified pediatric burn center. Participants were randomly assigned (1:1:1) to active VR (playing the VR), passive VR (immersed in the same VR environment without interactions), or standard-of-care. On a scale from 0 to 100, participants rated overall pain (primary outcome) and features of the VR experience (game realism, fun, and engagement). Path analysis assessed the interrelationships among these VR key features and their impact on self-reported pain scores. From December 2016 to January 2019, a total of 412 patients were screened for eligibility, and 90 were randomly assigned (31 in the active VR group, 30 in the passive VR group, and 29 in the standard-of-care group). The current study only included those in the VR groups. The difference in median scores of VR features was not statistically significant between the active (realism, 77.5 [IQR: 50-100]; fun, 100 [IQR: 81-100]; engagement, 90 [IQR: 70-100]) and passive (realism, 72 [IQR: 29-99]; fun, 93.5 [IQR: 68-100]; engagement, 95 [IQR: 50-100]) VR distraction types. VR engagement had a significant direct (-0.39) and total (-0.44) effect on self-reported pain score (p<0.05). Key VR features significantly impact its effectiveness in pain reduction. The path model suggested an analgesic mechanism beyond distraction. Differences in VR feature scores partly explain active VR's more significant analgesic effect than passive VR. Trial Registration: ClinicalTrials.gov Identifier: NCT04544631. |
| first_indexed | 2024-03-08T06:20:31Z |
| format | Article |
| id | doaj.art-85e3cc8190fe4cf9bfa6f004b9f120ad |
| institution | Directory Open Access Journal |
| issn | 2767-3170 |
| language | English |
| last_indexed | 2024-03-08T06:20:31Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Digital Health |
| spelling | doaj.art-85e3cc8190fe4cf9bfa6f004b9f120ad2024-02-04T05:32:07ZengPublic Library of Science (PLoS)PLOS Digital Health2767-31702024-01-0131e000044010.1371/journal.pdig.0000440Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial.Soumil JainMegan ArmstrongJohn LunaRajan K ThakkarRenata FabiaJonathan I GronerDana NoffsingerAi NiEric NelsonHenry XiangKey features of virtual reality (VR) that impact the effectiveness of pain reduction remain unknown. We hypothesized that specific features of the VR experience significantly impact VR's effectiveness in reducing pain during pediatric burn dressing care. Our randomized controlled trial included children 6 to 17 years (inclusive) who were treated in the outpatient clinic of an American Burn Association-verified pediatric burn center. Participants were randomly assigned (1:1:1) to active VR (playing the VR), passive VR (immersed in the same VR environment without interactions), or standard-of-care. On a scale from 0 to 100, participants rated overall pain (primary outcome) and features of the VR experience (game realism, fun, and engagement). Path analysis assessed the interrelationships among these VR key features and their impact on self-reported pain scores. From December 2016 to January 2019, a total of 412 patients were screened for eligibility, and 90 were randomly assigned (31 in the active VR group, 30 in the passive VR group, and 29 in the standard-of-care group). The current study only included those in the VR groups. The difference in median scores of VR features was not statistically significant between the active (realism, 77.5 [IQR: 50-100]; fun, 100 [IQR: 81-100]; engagement, 90 [IQR: 70-100]) and passive (realism, 72 [IQR: 29-99]; fun, 93.5 [IQR: 68-100]; engagement, 95 [IQR: 50-100]) VR distraction types. VR engagement had a significant direct (-0.39) and total (-0.44) effect on self-reported pain score (p<0.05). Key VR features significantly impact its effectiveness in pain reduction. The path model suggested an analgesic mechanism beyond distraction. Differences in VR feature scores partly explain active VR's more significant analgesic effect than passive VR. Trial Registration: ClinicalTrials.gov Identifier: NCT04544631.https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000440&type=printable |
| spellingShingle | Soumil Jain Megan Armstrong John Luna Rajan K Thakkar Renata Fabia Jonathan I Groner Dana Noffsinger Ai Ni Eric Nelson Henry Xiang Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. PLOS Digital Health |
| title | Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. |
| title_full | Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. |
| title_fullStr | Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. |
| title_full_unstemmed | Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. |
| title_short | Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial. |
| title_sort | features of virtual reality impact effectiveness of vr pain alleviation therapeutics in pediatric burn patients a randomized clinical trial |
| url | https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000440&type=printable |
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