Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case
Guillain — Barré syndrome (GBS) is a rare disease that occurs with an approximate incidence of 1.7 cases per 100,000 children in the pediatric population. The gender difference in the prevalence of the disease is characterized by a 20% greater vulnerability of boys than girls. The exact cause of G...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2022-03-01
|
| Series: | Zdorovʹe Rebenka |
| Subjects: | |
| Online Access: | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1491 |
| _version_ | 1811233261372833792 |
|---|---|
| author | O.K. Koloskova R.V. Tkachuk M.N. Garas T.M. Bilous L.I. Romanchuk D.I. Sorochan |
| author_facet | O.K. Koloskova R.V. Tkachuk M.N. Garas T.M. Bilous L.I. Romanchuk D.I. Sorochan |
| author_sort | O.K. Koloskova |
| collection | DOAJ |
| description | Guillain — Barré syndrome (GBS) is a rare disease that occurs with an approximate incidence of 1.7 cases per 100,000 children in the pediatric population. The gender difference in the prevalence of the disease is characterized by a 20% greater vulnerability of boys than girls. The exact cause of Guillain — Barre syndrome is unknown; however, it can occur after respiratory infection by Haemophilus influenzae, recent or ongoing Campylobacter jejuni infection or poliovirus. Since the beginning of the COVID-19 pandemic, there have been some reported Guillain — Barré diagnoses among adults following SARS-CoV-2 infection. The article describes a clinical case of an adolescent girl who was admitted to the Regional Municipal Non-Profit Facility “Chernivtsi Regional Children’s Clinical Hospital” with signs of flaccid paraplegia of the lower extremities, pelvic dysfunction and paraparesis of the upper extremities after she had suffered a sudden severe pain syndrome. She had previously been diagnosed with asymptomatic SARS-CoV-2. Initial complex investigations were as follows: high white blood cells count, elevated levels of procalcitonin (PCT), C-reactive protein and D-dimer, low SARS-CoV-2 IgM level and positive IgG titer, high levels of protein in spinal fluid. Electroneuromyography findings and nerve conduction test of lower extremities showed decreased M amplitude and H reflex response. The patient received oxygen therapy, hemodynamic support, cardiac support (infusions and inotrope therapy), gradual antibacterial therapy and was administrated with intravenous normal human immunoglobulin. She was also treated with a short course of parenteral glucocorticoids, vasoactive neurometabolites, nootropics, anticholinesterases, non-steroidal anti-inflammatory drugs along with physical therapy and massages. The patient began demonstrating slow but positive improvement in her limb motor functions and sensitivity within one month. |
| first_indexed | 2024-04-12T11:17:59Z |
| format | Article |
| id | doaj.art-85e57978126e4ad4b91f63df09b3262d |
| institution | Directory Open Access Journal |
| issn | 2224-0551 2307-1168 |
| language | English |
| last_indexed | 2024-04-12T11:17:59Z |
| publishDate | 2022-03-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Zdorovʹe Rebenka |
| spelling | doaj.art-85e57978126e4ad4b91f63df09b3262d2022-12-22T03:35:27ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682022-03-01171434710.22141/2224-0551.17.1.2022.14911491Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical caseO.K. Koloskova0https://orcid.org/0000-0002-4402-8756R.V. Tkachuk1https://orcid.org/0000-0002-6753-2365M.N. Garas2https://orcid.org/0000-0001-7304-2090T.M. Bilous3https://orcid.org/0000-0002-9469-401XL.I. Romanchuk4https://orcid.org/0000-0002-0676-3960D.I. Sorochan5Bukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, Ukraine; Regional Municipal Non-Profit Facility “Chernivtsi Regional Children’s Clinical Hospital”, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineRegional Municipal Non-Profit Facility “Chernivtsi Regional Children’s Clinical Hospital”, Chernivtsi, UkraineGuillain — Barré syndrome (GBS) is a rare disease that occurs with an approximate incidence of 1.7 cases per 100,000 children in the pediatric population. The gender difference in the prevalence of the disease is characterized by a 20% greater vulnerability of boys than girls. The exact cause of Guillain — Barre syndrome is unknown; however, it can occur after respiratory infection by Haemophilus influenzae, recent or ongoing Campylobacter jejuni infection or poliovirus. Since the beginning of the COVID-19 pandemic, there have been some reported Guillain — Barré diagnoses among adults following SARS-CoV-2 infection. The article describes a clinical case of an adolescent girl who was admitted to the Regional Municipal Non-Profit Facility “Chernivtsi Regional Children’s Clinical Hospital” with signs of flaccid paraplegia of the lower extremities, pelvic dysfunction and paraparesis of the upper extremities after she had suffered a sudden severe pain syndrome. She had previously been diagnosed with asymptomatic SARS-CoV-2. Initial complex investigations were as follows: high white blood cells count, elevated levels of procalcitonin (PCT), C-reactive protein and D-dimer, low SARS-CoV-2 IgM level and positive IgG titer, high levels of protein in spinal fluid. Electroneuromyography findings and nerve conduction test of lower extremities showed decreased M amplitude and H reflex response. The patient received oxygen therapy, hemodynamic support, cardiac support (infusions and inotrope therapy), gradual antibacterial therapy and was administrated with intravenous normal human immunoglobulin. She was also treated with a short course of parenteral glucocorticoids, vasoactive neurometabolites, nootropics, anticholinesterases, non-steroidal anti-inflammatory drugs along with physical therapy and massages. The patient began demonstrating slow but positive improvement in her limb motor functions and sensitivity within one month.https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1491guillain — barré syndromepolyneuropathychildrencovid-19 |
| spellingShingle | O.K. Koloskova R.V. Tkachuk M.N. Garas T.M. Bilous L.I. Romanchuk D.I. Sorochan Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case Zdorovʹe Rebenka guillain — barré syndrome polyneuropathy children covid-19 |
| title | Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case |
| title_full | Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case |
| title_fullStr | Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case |
| title_full_unstemmed | Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case |
| title_short | Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case |
| title_sort | guillain barre syndrome following asymptomatic covid 19 in an adolescent a clinical case |
| topic | guillain — barré syndrome polyneuropathy children covid-19 |
| url | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1491 |
| work_keys_str_mv | AT okkoloskova guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase AT rvtkachuk guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase AT mngaras guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase AT tmbilous guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase AT liromanchuk guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase AT disorochan guillainbarresyndromefollowingasymptomaticcovid19inanadolescentaclinicalcase |