Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites
Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-07-01
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| Series: | Contact |
| Online Access: | https://doi.org/10.1177/25152564211026505 |
| _version_ | 1811340612735074304 |
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| author | Vladimir Zhemkov Jen Liou Ilya Bezprozvanny |
| author_facet | Vladimir Zhemkov Jen Liou Ilya Bezprozvanny |
| author_sort | Vladimir Zhemkov |
| collection | DOAJ |
| description | Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains. |
| first_indexed | 2024-04-13T18:44:34Z |
| format | Article |
| id | doaj.art-85e80d5d11694b199f37b584528026fb |
| institution | Directory Open Access Journal |
| issn | 2515-2564 |
| language | English |
| last_indexed | 2024-04-13T18:44:34Z |
| publishDate | 2021-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj.art-85e80d5d11694b199f37b584528026fb2022-12-22T02:34:38ZengSAGE PublishingContact2515-25642021-07-01410.1177/25152564211026505Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact SitesVladimir ZhemkovJen LiouIlya BezprozvannyRecent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.https://doi.org/10.1177/25152564211026505 |
| spellingShingle | Vladimir Zhemkov Jen Liou Ilya Bezprozvanny Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites Contact |
| title | Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites |
| title_full | Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites |
| title_fullStr | Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites |
| title_full_unstemmed | Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites |
| title_short | Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites |
| title_sort | sigma 1 receptor cholesterol and endoplasmic reticulum contact sites |
| url | https://doi.org/10.1177/25152564211026505 |
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