Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet
<i>Prunus persica</i> and <i>Nelumbo nucifera</i> are major crops cultivated worldwide. In East Asia, both <i>P. persica</i> flowers and <i>N. nucifera</i> leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Her...
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3392 |
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| author | Jungbin Song Jiye Kim Hyo Jin Park Hocheol Kim |
| author_facet | Jungbin Song Jiye Kim Hyo Jin Park Hocheol Kim |
| author_sort | Jungbin Song |
| collection | DOAJ |
| description | <i>Prunus persica</i> and <i>Nelumbo nucifera</i> are major crops cultivated worldwide. In East Asia, both <i>P. persica</i> flowers and <i>N. nucifera</i> leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Herein, we investigated the anti-obesity effects of an herbal extract mixture of <i>P. persica</i> and <i>N. nucifera</i> (HT077) and the underlying mechanism using a high-fat diet (HFD)-induced obesity model. Male C57BL/6 mice were fed a normal diet, HFD, HFD containing 0.02% orlistat (positive control), or HFD containing 0.1, 0.2, or 0.4% HT077 for 12 weeks. HT077 significantly reduced final body weights, weight gain, abdominal fat weights, liver weights, and hepatic levels of triglycerides and total cholesterol. HT077 also lowered glucose, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and leptin levels and increased AST/ALT and adiponectin/leptin ratios and adiponectin levels. Real-time polymerase chain reaction analysis showed that HT077 decreased the expression of lipogenic genes and increased the expression of fatty acid oxidation-related genes in adipose tissue. Our results indicate that HT077 exerts anti-obesity effects and prevents the development of obesity-related metabolic disorders. These beneficial effects might be partially attributed to ameliorating adipokine imbalances and regulating lipid synthesis and fatty acid oxidation in adipose tissue. |
| first_indexed | 2024-03-10T15:06:13Z |
| format | Article |
| id | doaj.art-85e8dc8a141242f2960145a67b0e9ad9 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:06:13Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-85e8dc8a141242f2960145a67b0e9ad92023-11-20T19:46:31ZengMDPI AGNutrients2072-66432020-11-011211339210.3390/nu12113392Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat DietJungbin Song0Jiye Kim1Hyo Jin Park2Hocheol Kim3Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaKorea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea<i>Prunus persica</i> and <i>Nelumbo nucifera</i> are major crops cultivated worldwide. In East Asia, both <i>P. persica</i> flowers and <i>N. nucifera</i> leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Herein, we investigated the anti-obesity effects of an herbal extract mixture of <i>P. persica</i> and <i>N. nucifera</i> (HT077) and the underlying mechanism using a high-fat diet (HFD)-induced obesity model. Male C57BL/6 mice were fed a normal diet, HFD, HFD containing 0.02% orlistat (positive control), or HFD containing 0.1, 0.2, or 0.4% HT077 for 12 weeks. HT077 significantly reduced final body weights, weight gain, abdominal fat weights, liver weights, and hepatic levels of triglycerides and total cholesterol. HT077 also lowered glucose, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and leptin levels and increased AST/ALT and adiponectin/leptin ratios and adiponectin levels. Real-time polymerase chain reaction analysis showed that HT077 decreased the expression of lipogenic genes and increased the expression of fatty acid oxidation-related genes in adipose tissue. Our results indicate that HT077 exerts anti-obesity effects and prevents the development of obesity-related metabolic disorders. These beneficial effects might be partially attributed to ameliorating adipokine imbalances and regulating lipid synthesis and fatty acid oxidation in adipose tissue.https://www.mdpi.com/2072-6643/12/11/3392<i>Prunus persica</i><i>Nelumbo nucifera</i>high-fat dietadipokinefatty acid oxidationlipid synthesis |
| spellingShingle | Jungbin Song Jiye Kim Hyo Jin Park Hocheol Kim Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet Nutrients <i>Prunus persica</i> <i>Nelumbo nucifera</i> high-fat diet adipokine fatty acid oxidation lipid synthesis |
| title | Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet |
| title_full | Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet |
| title_fullStr | Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet |
| title_full_unstemmed | Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet |
| title_short | Anti-Obesity Effects of a <i>Prunus persica</i> and <i>Nelumbo nucifera</i> Mixture in Mice Fed a High-Fat Diet |
| title_sort | anti obesity effects of a i prunus persica i and i nelumbo nucifera i mixture in mice fed a high fat diet |
| topic | <i>Prunus persica</i> <i>Nelumbo nucifera</i> high-fat diet adipokine fatty acid oxidation lipid synthesis |
| url | https://www.mdpi.com/2072-6643/12/11/3392 |
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