Implantable device actuated by manual button clicks for noninvasive self‐drug administration
Abstract Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a fully implantable device capable of on‐demand administration of self‐injection drugs...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10320 |
| _version_ | 1797270780277424128 |
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| author | Cho Rim Kim Yong Chan Cho Seung Ho Lee Jae Hoon Han Min Ji Kim Han Bi Ji Se‐Na Kim Chang Hee Min Byung Ho Shin Cheol Lee Young Min Cho Young Bin Choy |
| author_facet | Cho Rim Kim Yong Chan Cho Seung Ho Lee Jae Hoon Han Min Ji Kim Han Bi Ji Se‐Na Kim Chang Hee Min Byung Ho Shin Cheol Lee Young Min Cho Young Bin Choy |
| author_sort | Cho Rim Kim |
| collection | DOAJ |
| description | Abstract Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a fully implantable device capable of on‐demand administration of self‐injection drugs via noninvasive manual button clicks on the outer skin. The device is designed to infuse the drug only at the moment of click actuation, which allows for an accurate and reproducible drug infusion, and also prevents unwanted drug leakage. Using a mechanical means of drug infusion, this implantable device does not contain any electronic compartments or batteries, making it compact, and semi‐permanent. When tested in animals, the device can achieve subcutaneous injection‐like pharmacokinetic and pharmacodynamic effects for self‐injection drugs such as exenatide, insulin, and glucagon. |
| first_indexed | 2024-04-25T02:09:42Z |
| format | Article |
| id | doaj.art-85ea83c4ca694ff595ec8540f205a579 |
| institution | Directory Open Access Journal |
| issn | 2380-6761 |
| language | English |
| last_indexed | 2024-04-25T02:09:42Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj.art-85ea83c4ca694ff595ec8540f205a5792024-03-07T12:20:54ZengWileyBioengineering & Translational Medicine2380-67612023-01-0181n/an/a10.1002/btm2.10320Implantable device actuated by manual button clicks for noninvasive self‐drug administrationCho Rim Kim0Yong Chan Cho1Seung Ho Lee2Jae Hoon Han3Min Ji Kim4Han Bi Ji5Se‐Na Kim6Chang Hee Min7Byung Ho Shin8Cheol Lee9Young Min Cho10Young Bin Choy11Interdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaInterdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaInstitute of Medical and Biological Engineering, Medical Research Center Seoul National University Seoul South KoreaInterdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaInterdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaInterdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaInstitute of Medical and Biological Engineering, Medical Research Center Seoul National University Seoul South KoreaInstitute of Medical and Biological Engineering, Medical Research Center Seoul National University Seoul South KoreaDepartment of Biomedical Engineering Seoul National University College of Medicine Seoul South KoreaDepartment of Pathology Seoul National University College of Medicine Seoul South KoreaDepartment of Internal Medicine Seoul National University College of Medicine Seoul South KoreaInterdisciplinary Program in Bioengineering, College of Engineering Seoul National University Seoul South KoreaAbstract Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a fully implantable device capable of on‐demand administration of self‐injection drugs via noninvasive manual button clicks on the outer skin. The device is designed to infuse the drug only at the moment of click actuation, which allows for an accurate and reproducible drug infusion, and also prevents unwanted drug leakage. Using a mechanical means of drug infusion, this implantable device does not contain any electronic compartments or batteries, making it compact, and semi‐permanent. When tested in animals, the device can achieve subcutaneous injection‐like pharmacokinetic and pharmacodynamic effects for self‐injection drugs such as exenatide, insulin, and glucagon.https://doi.org/10.1002/btm2.10320implantable devicemetabolic disorderson‐demand drug deliveryself‐injectable therapy |
| spellingShingle | Cho Rim Kim Yong Chan Cho Seung Ho Lee Jae Hoon Han Min Ji Kim Han Bi Ji Se‐Na Kim Chang Hee Min Byung Ho Shin Cheol Lee Young Min Cho Young Bin Choy Implantable device actuated by manual button clicks for noninvasive self‐drug administration Bioengineering & Translational Medicine implantable device metabolic disorders on‐demand drug delivery self‐injectable therapy |
| title | Implantable device actuated by manual button clicks for noninvasive self‐drug administration |
| title_full | Implantable device actuated by manual button clicks for noninvasive self‐drug administration |
| title_fullStr | Implantable device actuated by manual button clicks for noninvasive self‐drug administration |
| title_full_unstemmed | Implantable device actuated by manual button clicks for noninvasive self‐drug administration |
| title_short | Implantable device actuated by manual button clicks for noninvasive self‐drug administration |
| title_sort | implantable device actuated by manual button clicks for noninvasive self drug administration |
| topic | implantable device metabolic disorders on‐demand drug delivery self‐injectable therapy |
| url | https://doi.org/10.1002/btm2.10320 |
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