Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes?
Whether the primary Hepatitis B vaccination confers lifelong protection is debated. The aim of the study was to assess the effectiveness of booster doses in mounting a protective HBV immune response in subjects vaccinated 18–20 years earlier. The study population consisted of vaccinated students att...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/2/227 |
| _version_ | 1797567808452689920 |
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| author | Rosa Papadopoli Caterina De Sarro Carlo Torti Claudia Pileggi Maria Pavia |
| author_facet | Rosa Papadopoli Caterina De Sarro Carlo Torti Claudia Pileggi Maria Pavia |
| author_sort | Rosa Papadopoli |
| collection | DOAJ |
| description | Whether the primary Hepatitis B vaccination confers lifelong protection is debated. The aim of the study was to assess the effectiveness of booster doses in mounting a protective HBV immune response in subjects vaccinated 18–20 years earlier. The study population consisted of vaccinated students attending medical and healthcare professions schools. A booster dose was offered to subjects with a <10 mIU/mL anti-HBs titer. The post-booster anti-HBs titer was evaluated after four weeks. The subjects with a <10 mIU/mL post-booster anti-HBs titer, received a second and third dose of the vaccine and after one month they were retested. A <10 mIU/mL anti-HBs titer was found in 35.1% of the participants and 92.2% of subjects that were boosted had a ≥10 mIU/mL post-booster anti-HBs titer, whereas 7.8% did not mount an anamnestic response. A low post-booster response (10–100 mIU/mL anti-HBs) was significantly more likely in subjects with a <2.00 mIU/mL pre-booster titer compared to those with a 2.00–9.99 mIU/mL pre-booster titer. The anamnestic response was significantly related to the baseline anti-HBs levels. A booster dose of the HBV vaccine may be insufficient to induce an immunological response in subjects with undetectable anti-HBs titers. A booster dose might be implemented when an anamnestic response is still present. |
| first_indexed | 2024-03-10T19:47:43Z |
| format | Article |
| id | doaj.art-85eafffd22e644a6b43fe89e679fa0db |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T19:47:43Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-85eafffd22e644a6b43fe89e679fa0db2023-11-20T00:41:52ZengMDPI AGVaccines2076-393X2020-05-018222710.3390/vaccines8020227Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes?Rosa Papadopoli0Caterina De Sarro1Carlo Torti2Claudia Pileggi3Maria Pavia4Department of Health Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Health Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Health Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, ItalyDepartment of Health Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, ItalyWhether the primary Hepatitis B vaccination confers lifelong protection is debated. The aim of the study was to assess the effectiveness of booster doses in mounting a protective HBV immune response in subjects vaccinated 18–20 years earlier. The study population consisted of vaccinated students attending medical and healthcare professions schools. A booster dose was offered to subjects with a <10 mIU/mL anti-HBs titer. The post-booster anti-HBs titer was evaluated after four weeks. The subjects with a <10 mIU/mL post-booster anti-HBs titer, received a second and third dose of the vaccine and after one month they were retested. A <10 mIU/mL anti-HBs titer was found in 35.1% of the participants and 92.2% of subjects that were boosted had a ≥10 mIU/mL post-booster anti-HBs titer, whereas 7.8% did not mount an anamnestic response. A low post-booster response (10–100 mIU/mL anti-HBs) was significantly more likely in subjects with a <2.00 mIU/mL pre-booster titer compared to those with a 2.00–9.99 mIU/mL pre-booster titer. The anamnestic response was significantly related to the baseline anti-HBs levels. A booster dose of the HBV vaccine may be insufficient to induce an immunological response in subjects with undetectable anti-HBs titers. A booster dose might be implemented when an anamnestic response is still present.https://www.mdpi.com/2076-393X/8/2/227baseline anti-HBs levelsbooster doseHBV vaccinelifelong protection |
| spellingShingle | Rosa Papadopoli Caterina De Sarro Carlo Torti Claudia Pileggi Maria Pavia Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? Vaccines baseline anti-HBs levels booster dose HBV vaccine lifelong protection |
| title | Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? |
| title_full | Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? |
| title_fullStr | Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? |
| title_full_unstemmed | Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? |
| title_short | Is There Any Opportunity to Provide an HBV Vaccine Booster Dose before Anti-Hbs Titer Vanishes? |
| title_sort | is there any opportunity to provide an hbv vaccine booster dose before anti hbs titer vanishes |
| topic | baseline anti-HBs levels booster dose HBV vaccine lifelong protection |
| url | https://www.mdpi.com/2076-393X/8/2/227 |
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