Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals
Quercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity. The labeling procedure was conducted by the...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2019-08-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/34512 |
| _version_ | 1818695768066752512 |
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| author | Maula Eka Sriyani Dian Ayu Utami Mega Susilo Dwike Eva Maria Widyasari Muharram Marzuki Rizky Juwita Sugiharti Witri Nuraeni |
| author_facet | Maula Eka Sriyani Dian Ayu Utami Mega Susilo Dwike Eva Maria Widyasari Muharram Marzuki Rizky Juwita Sugiharti Witri Nuraeni |
| author_sort | Maula Eka Sriyani |
| collection | DOAJ |
| description | Quercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity. The labeling procedure was conducted by the oxidation reaction using chloramine-T. The effect of pH, reaction time, amount of oxidizing agent and ligand were evaluated in this research. Quercetin was successfully labeled with iodine-131 at pH 11 at room temperature for 10 min mixed in 1000 rpm with the amount of quercetin and chloramine-T is 0.4 and 0.3 mg, respectively. The results demonstrated that the ratio of quercetin/Na131I was 2 × 105. The 131I-quercetin labeling efficiency was 92.03 ± 2.20%, and radiochemical purity of 131I-quercetin was 99.34 ± 0.58%. The results showed that 131I-quercetin could be a radiotracer candidate for diagnosis and cancer therapy. |
| first_indexed | 2024-12-17T13:50:43Z |
| format | Article |
| id | doaj.art-85eb9c70021549d88cd75e7d7ce10a94 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-17T13:50:43Z |
| publishDate | 2019-08-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-85eb9c70021549d88cd75e7d7ce10a942022-12-21T21:46:02ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782019-08-0119484184810.22146/ijc.3451224633Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer RadiopharmaceuticalsMaula Eka Sriyani0Dian Ayu Utami1Mega Susilo Dwike2Eva Maria Widyasari3Muharram Marzuki4Rizky Juwita Sugiharti5Witri Nuraeni6National Nuclear Energy Agency, Jl. Tamansari No. 71 Bandung 40132, IndonesiaJenderal Achmad Yani University, Jl. Terusan Jenderal Sudirman Cimahi, IndonesiaJenderal Achmad Yani University, Jl. Terusan Jenderal Sudirman Cimahi, IndonesiaNational Nuclear Energy Agency, Jl. Tamansari No. 71 Bandung 40132, IndonesiaJenderal Achmad Yani University, Jl. Terusan Jenderal Sudirman Cimahi, IndonesiaNational Nuclear Energy Agency, Jl. Tamansari No. 71 Bandung 40132, IndonesiaNational Nuclear Energy Agency, Jl. Tamansari No. 71 Bandung 40132, IndonesiaQuercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity. The labeling procedure was conducted by the oxidation reaction using chloramine-T. The effect of pH, reaction time, amount of oxidizing agent and ligand were evaluated in this research. Quercetin was successfully labeled with iodine-131 at pH 11 at room temperature for 10 min mixed in 1000 rpm with the amount of quercetin and chloramine-T is 0.4 and 0.3 mg, respectively. The results demonstrated that the ratio of quercetin/Na131I was 2 × 105. The 131I-quercetin labeling efficiency was 92.03 ± 2.20%, and radiochemical purity of 131I-quercetin was 99.34 ± 0.58%. The results showed that 131I-quercetin could be a radiotracer candidate for diagnosis and cancer therapy.https://jurnal.ugm.ac.id/ijc/article/view/34512131I-quercetiniodinationnatural compoundsynthesisanticancer |
| spellingShingle | Maula Eka Sriyani Dian Ayu Utami Mega Susilo Dwike Eva Maria Widyasari Muharram Marzuki Rizky Juwita Sugiharti Witri Nuraeni Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals Indonesian Journal of Chemistry 131I-quercetin iodination natural compound synthesis anticancer |
| title | Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals |
| title_full | Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals |
| title_fullStr | Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals |
| title_full_unstemmed | Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals |
| title_short | Synthesis of <sup>131</sup>I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals |
| title_sort | synthesis of sup 131 sup i labeled quercetin through oxidation method using chloramine t for cancer radiopharmaceuticals |
| topic | 131I-quercetin iodination natural compound synthesis anticancer |
| url | https://jurnal.ugm.ac.id/ijc/article/view/34512 |
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