Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats

Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats

Severe muscle weakness concomitant with preferential depletion of myosin has been observed in several pathological conditions. Here, we used the steroid-denervation (S-D) rat model, which shows dramatic decrease in myosin content and force production, to test whether electrical stimulation (ES) trea...

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Bibliographic Details
Main Authors: Takashi Yamada, Koichi Himori, Daisuke Tatebayashi, Ryotaro Yamada, Yuki Ashida, Tomihiro Imai, Masayuki Akatsuka, Yoshiki Masuda, Keita Kanzaki, Daiki Watanabe, Masanobu Wada, Håkan Westerblad, Johanna T. Lanner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
muscle weakness
myosin loss
myofibrillar dysfunction
oxidative stress
electrical stimulation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01111/full

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