Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study
Background: Recently, non-invasive ventilation has been widely used due to the reduction of adverse effects of endotracheal intubation. Nevertheless nearly no researches have compared the efficacy of non-invasive respiratory support between preterm twins. The objective of this study was to determine...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-04-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/4/10.31083/j.ceog4904084 |
| _version_ | 1818232087935713280 |
|---|---|
| author | Xingmei Deng Huiling Cao Chunxiu Zhang Hong Yang Yuan Shi Fang Li Chuanfeng Li |
| author_facet | Xingmei Deng Huiling Cao Chunxiu Zhang Hong Yang Yuan Shi Fang Li Chuanfeng Li |
| author_sort | Xingmei Deng |
| collection | DOAJ |
| description | Background: Recently, non-invasive ventilation has been widely used due to the reduction of adverse effects of endotracheal intubation. Nevertheless nearly no researches have compared the efficacy of non-invasive respiratory support between preterm twins. The objective of this study was to determine if there is a decreased non-invasive ventilation (NIV) failure from bi-level positive airway pressure (Bi-PAP) vs nasal continuous positive airway pressure (NCPAP) in preterm twins as initial ventilation. Methods: This prospective cohort study enrolled 100 pairs preterm twins who were admitted to the NICU at Yunnan Qujing Maternity and Child Health Care Hospital from 2017.10 to 2020.09 for respiratory distress syndrome. One of the twin was randomly assigned to Bi-PAP, meanwhile another to NCPAP. The primary outcome was the incidence of NIV failure. Secondary outcomes was the occurrence rate of side-effects of NIV. Results: A total of 100 pairs preterm twins were included in statistical analysis. No distinct differences were found in NIV failure between groups (NCPAP vs Bi-PAP, 5% vs 2%, p = 0.248). We did not find any statistical difference in secondary outcome between Bi-PAP and NCPAP. Conclusions: In this prospective cohort study, among preterm twins with RDS, NCPAP was noninferior to Bi-PAP with respect to the reduction of the need for invasive mechanical ventilation (IMV). |
| first_indexed | 2024-12-12T11:00:43Z |
| format | Article |
| id | doaj.art-85ec5379a8fa499a8e77468ad1ebbc8e |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T11:00:43Z |
| publishDate | 2022-04-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-85ec5379a8fa499a8e77468ad1ebbc8e2022-12-22T00:26:32ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-04-014948410.31083/j.ceog4904084S0390-6663(22)01738-9Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort studyXingmei Deng0Huiling Cao1Chunxiu Zhang2Hong Yang3Yuan Shi4Fang Li5Chuanfeng Li6Department of Pediatrics, Qujing Maternal and Child Health Hospital, 655000 Qujing, Yunnan, ChinaDepartment of Neonatology, Children's Hospital of Chongqing Medical University, 400000 Chongqing, ChinaDepartment of Pediatrics, Qujing Maternal and Child Health Hospital, 655000 Qujing, Yunnan, ChinaDepartment of Pediatrics, Qujing Maternal and Child Health Hospital, 655000 Qujing, Yunnan, ChinaDepartment of Neonatology, Children's Hospital of Chongqing Medical University, 400000 Chongqing, ChinaDepartment of Neonatology, Children's Hospital of Chongqing Medical University, 400000 Chongqing, ChinaDepartment of Pediatrics, Qujing Maternal and Child Health Hospital, 655000 Qujing, Yunnan, ChinaBackground: Recently, non-invasive ventilation has been widely used due to the reduction of adverse effects of endotracheal intubation. Nevertheless nearly no researches have compared the efficacy of non-invasive respiratory support between preterm twins. The objective of this study was to determine if there is a decreased non-invasive ventilation (NIV) failure from bi-level positive airway pressure (Bi-PAP) vs nasal continuous positive airway pressure (NCPAP) in preterm twins as initial ventilation. Methods: This prospective cohort study enrolled 100 pairs preterm twins who were admitted to the NICU at Yunnan Qujing Maternity and Child Health Care Hospital from 2017.10 to 2020.09 for respiratory distress syndrome. One of the twin was randomly assigned to Bi-PAP, meanwhile another to NCPAP. The primary outcome was the incidence of NIV failure. Secondary outcomes was the occurrence rate of side-effects of NIV. Results: A total of 100 pairs preterm twins were included in statistical analysis. No distinct differences were found in NIV failure between groups (NCPAP vs Bi-PAP, 5% vs 2%, p = 0.248). We did not find any statistical difference in secondary outcome between Bi-PAP and NCPAP. Conclusions: In this prospective cohort study, among preterm twins with RDS, NCPAP was noninferior to Bi-PAP with respect to the reduction of the need for invasive mechanical ventilation (IMV).https://www.imrpress.com/journal/CEOG/49/4/10.31083/j.ceog4904084respiratory distress syndromebi-level positive airway pressurenasal continuous positive airway pressurepreterm twins |
| spellingShingle | Xingmei Deng Huiling Cao Chunxiu Zhang Hong Yang Yuan Shi Fang Li Chuanfeng Li Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study Clinical and Experimental Obstetrics & Gynecology respiratory distress syndrome bi-level positive airway pressure nasal continuous positive airway pressure preterm twins |
| title | Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study |
| title_full | Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study |
| title_fullStr | Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study |
| title_full_unstemmed | Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study |
| title_short | Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study |
| title_sort | bi pap is not superior to ncpap in the premature twins with respiratory distress syndrome a prospective cohort study |
| topic | respiratory distress syndrome bi-level positive airway pressure nasal continuous positive airway pressure preterm twins |
| url | https://www.imrpress.com/journal/CEOG/49/4/10.31083/j.ceog4904084 |
| work_keys_str_mv | AT xingmeideng bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT huilingcao bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT chunxiuzhang bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT hongyang bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT yuanshi bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT fangli bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy AT chuanfengli bipapisnotsuperiortoncpapintheprematuretwinswithrespiratorydistresssyndromeaprospectivecohortstudy |