Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors
Purpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment. Observations: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease foll...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624000318 |
| _version_ | 1827248094441373696 |
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| author | Jasmine H. Francis Christopher A. Barker Julia Canestraro David H. Abramson Alexander N. Shoushtari |
| author_facet | Jasmine H. Francis Christopher A. Barker Julia Canestraro David H. Abramson Alexander N. Shoushtari |
| author_sort | Jasmine H. Francis |
| collection | DOAJ |
| description | Purpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment. Observations: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up. Conclusions and importance: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors. |
| first_indexed | 2024-03-07T19:09:26Z |
| format | Article |
| id | doaj.art-85ecccdae4fc43129f0a26b190d55dc8 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2025-03-21T23:26:17Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-85ecccdae4fc43129f0a26b190d55dc82024-05-20T04:08:31ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362024-06-0134102021Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitorsJasmine H. Francis0Christopher A. Barker1Julia Canestraro2David H. Abramson3Alexander N. Shoushtari4Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Corresponding author. Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USAOphthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USAOphthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USADepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USAPurpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment. Observations: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up. Conclusions and importance: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.http://www.sciencedirect.com/science/article/pii/S2451993624000318Metastatic uveal melanomaCirculating tumor DNACell free DNAImmunotherapyImmune checkpoint inhibition |
| spellingShingle | Jasmine H. Francis Christopher A. Barker Julia Canestraro David H. Abramson Alexander N. Shoushtari Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors American Journal of Ophthalmology Case Reports Metastatic uveal melanoma Circulating tumor DNA Cell free DNA Immunotherapy Immune checkpoint inhibition |
| title | Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| title_full | Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| title_fullStr | Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| title_full_unstemmed | Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| title_short | Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| title_sort | clearance of plasma cell free dna in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors |
| topic | Metastatic uveal melanoma Circulating tumor DNA Cell free DNA Immunotherapy Immune checkpoint inhibition |
| url | http://www.sciencedirect.com/science/article/pii/S2451993624000318 |
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