Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target
Abstract Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosq...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-40029-y |
| _version_ | 1797774093656784896 |
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| author | Marcos Georgiades Alexandros Alampounti Jason Somers Matthew P. Su David A. Ellis Judit Bagi Daniela Terrazas-Duque Scott Tytheridge Watson Ntabaliba Sarah Moore Joerg T. Albert Marta Andrés |
| author_facet | Marcos Georgiades Alexandros Alampounti Jason Somers Matthew P. Su David A. Ellis Judit Bagi Daniela Terrazas-Duque Scott Tytheridge Watson Ntabaliba Sarah Moore Joerg T. Albert Marta Andrés |
| author_sort | Marcos Georgiades |
| collection | DOAJ |
| description | Abstract Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosquito audition, the mechanisms of which are largely unknown. Using transcriptomics, we identify a complex network of candidate neuromodulators regulating mosquito hearing in the species Anopheles gambiae. Among them, octopamine stands out as an auditory modulator during swarm time. In-depth analysis of octopamine auditory function shows that it affects the mosquito ear on multiple levels: it modulates the tuning and stiffness of the flagellar sound receiver and controls the erection of antennal fibrillae. We show that two α- and β-adrenergic-like octopamine receptors drive octopamine’s auditory roles and demonstrate that the octopaminergic auditory control system can be targeted by insecticides. Our findings highlight octopamine as key for mosquito hearing and mating partner detection and as a potential novel target for mosquito control. |
| first_indexed | 2024-03-12T22:16:01Z |
| format | Article |
| id | doaj.art-85ee92b2cb6e43c18532c551bb908064 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T22:16:01Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-85ee92b2cb6e43c18532c551bb9080642023-07-23T11:19:11ZengNature PortfolioNature Communications2041-17232023-07-0114112010.1038/s41467-023-40029-yHearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide targetMarcos Georgiades0Alexandros Alampounti1Jason Somers2Matthew P. Su3David A. Ellis4Judit Bagi5Daniela Terrazas-Duque6Scott Tytheridge7Watson Ntabaliba8Sarah Moore9Joerg T. Albert10Marta Andrés11Ear Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonEar Institute, University College LondonVector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Sciences, Ifakara Health InstituteVector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Sciences, Ifakara Health InstituteEar Institute, University College LondonEar Institute, University College LondonAbstract Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosquito audition, the mechanisms of which are largely unknown. Using transcriptomics, we identify a complex network of candidate neuromodulators regulating mosquito hearing in the species Anopheles gambiae. Among them, octopamine stands out as an auditory modulator during swarm time. In-depth analysis of octopamine auditory function shows that it affects the mosquito ear on multiple levels: it modulates the tuning and stiffness of the flagellar sound receiver and controls the erection of antennal fibrillae. We show that two α- and β-adrenergic-like octopamine receptors drive octopamine’s auditory roles and demonstrate that the octopaminergic auditory control system can be targeted by insecticides. Our findings highlight octopamine as key for mosquito hearing and mating partner detection and as a potential novel target for mosquito control.https://doi.org/10.1038/s41467-023-40029-y |
| spellingShingle | Marcos Georgiades Alexandros Alampounti Jason Somers Matthew P. Su David A. Ellis Judit Bagi Daniela Terrazas-Duque Scott Tytheridge Watson Ntabaliba Sarah Moore Joerg T. Albert Marta Andrés Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target Nature Communications |
| title | Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target |
| title_full | Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target |
| title_fullStr | Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target |
| title_full_unstemmed | Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target |
| title_short | Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target |
| title_sort | hearing of malaria mosquitoes is modulated by a beta adrenergic like octopamine receptor which serves as insecticide target |
| url | https://doi.org/10.1038/s41467-023-40029-y |
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