Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study
Abstract It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the develop...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51455-3 |
| _version_ | 1827573075522093056 |
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| author | Chan Hyung Lee Kyungdo Han Hyun Jung Lee Hosun Yu Seulji Kim Kookhwan Choi Seong-Joon Koh Jong Pil Im Joo Sung Kim |
| author_facet | Chan Hyung Lee Kyungdo Han Hyun Jung Lee Hosun Yu Seulji Kim Kookhwan Choi Seong-Joon Koh Jong Pil Im Joo Sung Kim |
| author_sort | Chan Hyung Lee |
| collection | DOAJ |
| description | Abstract It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD. This nationwide population-based cohort study was conducted using the Korean National Health Insurance Service (NHIS) database. A total of 10,628,070 people aged 20 years or older who had undergone a national health examination conducted by the NHIS in 2009 were followed up until 2017. The study population was divided into two groups according to the presence or absence of migraine. We analyzed the incidence of newly developed IBD, Crohn’s disease (CD), or ulcerative colitis (UC) during the follow-up period. The incidence of IBD was significantly higher in patients with migraine (adjusted hazard ratio [aHR] with 95% confidence interval [95%CI] of 1.31 [1.173–1.468], p < 0.001), CD (aHR with 95%CI of 1.58 [1.237–2.013], p < 0.001) and UC (aHR with 95%CI of 1.26 [1.106–1.424], p < 0.001) than in those without migraine. After 5 years of follow-up, those with migraine showed curves implying cumulative incidences of IBD with a steep increase, especially for CD. In subgroup analysis, migraine was associated with the risk of UC in males (aHR, 1.431 vs. 1.117; interaction p = 0.042). Migraine is significantly associated with the development of IBD. Patients with migraine should be monitored carefully for the development of IBD. |
| first_indexed | 2024-03-08T14:17:17Z |
| format | Article |
| id | doaj.art-85eea6885e154248aa5a9d4eae8ad5ad |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T14:17:17Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-85eea6885e154248aa5a9d4eae8ad5ad2024-01-14T12:21:20ZengNature PortfolioScientific Reports2045-23222024-01-011411810.1038/s41598-024-51455-3Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based studyChan Hyung Lee0Kyungdo Han1Hyun Jung Lee2Hosun Yu3Seulji Kim4Kookhwan Choi5Seong-Joon Koh6Jong Pil Im7Joo Sung Kim8Department of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of MedicineAbstract It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD. This nationwide population-based cohort study was conducted using the Korean National Health Insurance Service (NHIS) database. A total of 10,628,070 people aged 20 years or older who had undergone a national health examination conducted by the NHIS in 2009 were followed up until 2017. The study population was divided into two groups according to the presence or absence of migraine. We analyzed the incidence of newly developed IBD, Crohn’s disease (CD), or ulcerative colitis (UC) during the follow-up period. The incidence of IBD was significantly higher in patients with migraine (adjusted hazard ratio [aHR] with 95% confidence interval [95%CI] of 1.31 [1.173–1.468], p < 0.001), CD (aHR with 95%CI of 1.58 [1.237–2.013], p < 0.001) and UC (aHR with 95%CI of 1.26 [1.106–1.424], p < 0.001) than in those without migraine. After 5 years of follow-up, those with migraine showed curves implying cumulative incidences of IBD with a steep increase, especially for CD. In subgroup analysis, migraine was associated with the risk of UC in males (aHR, 1.431 vs. 1.117; interaction p = 0.042). Migraine is significantly associated with the development of IBD. Patients with migraine should be monitored carefully for the development of IBD.https://doi.org/10.1038/s41598-024-51455-3 |
| spellingShingle | Chan Hyung Lee Kyungdo Han Hyun Jung Lee Hosun Yu Seulji Kim Kookhwan Choi Seong-Joon Koh Jong Pil Im Joo Sung Kim Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study Scientific Reports |
| title | Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study |
| title_full | Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study |
| title_fullStr | Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study |
| title_full_unstemmed | Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study |
| title_short | Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study |
| title_sort | migraine is associated with the development of adult patients with inflammatory bowel disease a nationwide population based study |
| url | https://doi.org/10.1038/s41598-024-51455-3 |
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