Lithium produces bi-directionally regulation of mood disturbance, acts synergistically with anti-depressive/-manic agents, and did not deteriorate the cognitive impairment in murine model of bipolar disorder

Lithium produces bi-directionally regulation of mood disturbance, acts synergistically with anti-depressive/-manic agents, and did not deteriorate the cognitive impairment in murine model of bipolar disorder

Abstract Lithium (Li) is a well-established mood disorder treatment and may be neuroprotective. Bi-directional regulation (i.e. affecting manic symptoms and depressive symptoms) by Li has not been demonstrated. This study explored: (1) bidirectional regulation by Li in murine models of depression, m...

Cijeli opis

Bibliografski detalji
Glavni autori: Chuanjun Zhuo, Chunhua Zhou, Hongjun Tian, Qianchen Li, Jiayue Chen, Lei Yang, Qiuyu Zhang, Ranli Li, Xiaoyan Ma, Ziyao Cai, Guangdong Chen, Yong Xu, Xueqin Song
Format: Članak
Jezik:English
Izdano: Nature Publishing Group 2022-09-01
Serija:Translational Psychiatry
Online pristup:https://doi.org/10.1038/s41398-022-02087-6

Internet

https://doi.org/10.1038/s41398-022-02087-6

Slični predmeti