Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway
The development of neuroprotective agents has important clinical significance. Bavachin is a flavonoid compound in Psoralea corylifolia, which has multiple biological activities, however its neuroprotective effect and molecular mechanism remain unclear. We found that bavachin inhibited neuroinflamma...
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| Format: | Article |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002554 |
| _version_ | 1797749182382997504 |
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| author | Xiao Zhang Yaping Guo Zhonghong Zhang Xintong Wu Li Li Zhiping Yang Zhipeng Li |
| author_facet | Xiao Zhang Yaping Guo Zhonghong Zhang Xintong Wu Li Li Zhiping Yang Zhipeng Li |
| author_sort | Xiao Zhang |
| collection | DOAJ |
| description | The development of neuroprotective agents has important clinical significance. Bavachin is a flavonoid compound in Psoralea corylifolia, which has multiple biological activities, however its neuroprotective effect and molecular mechanism remain unclear. We found that bavachin inhibited neuroinflammation and also exerted significant antioxidative stress effects. Furthermore, we found that bavachin exerted neuronal protective and anti-apoptotic effects. Further studies showed that bavachin increased Bcl-2 expression, while inhibited Bax expression, and also inhibited the decrease of mitochondrial membrane potential. As for the mechanism, the results displayed that bavachin upregulated Sirt1 and Nrf2 expression in vitro and in vivo, and inhibited the phosphorylation level of p65 in vivo. Taken as a conclusion, this study first provided evidence that bavachin inhibited neuronal damage caused by neuroinflammation and oxidative stress through the activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway, and bavachin might be a potential candidate for treating neurodegenerative diseases. |
| first_indexed | 2024-03-12T16:15:36Z |
| format | Article |
| id | doaj.art-85ef6527fe0348b39dd5cf043fff17bd |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:36Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-85ef6527fe0348b39dd5cf043fff17bd2023-08-09T04:32:28ZengElsevierJournal of Functional Foods1756-46462023-08-01107105655Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathwayXiao Zhang0Yaping Guo1Zhonghong Zhang2Xintong Wu3Li Li4Zhiping Yang5Zhipeng Li6School of Pharmacy, Binzhou Medical University, Yantai, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, ChinaDepartment of Pharmacy, Zhejiang Hospital, Hangzhou 310013, Zhejiang, ChinaDepartment of Clinical Nutrition, The First Affiliated Hospital of Xiamen University, Xiamen, China; Corresponding authors at: School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, China. (Z.L) Department of Clinical Nutrition, The First Affiliated Hospital of Xiamen University, Xiamen, China (Z.Y).School of Pharmacy, Binzhou Medical University, Yantai, Shandong, China; Corresponding authors at: School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, China. (Z.L) Department of Clinical Nutrition, The First Affiliated Hospital of Xiamen University, Xiamen, China (Z.Y).The development of neuroprotective agents has important clinical significance. Bavachin is a flavonoid compound in Psoralea corylifolia, which has multiple biological activities, however its neuroprotective effect and molecular mechanism remain unclear. We found that bavachin inhibited neuroinflammation and also exerted significant antioxidative stress effects. Furthermore, we found that bavachin exerted neuronal protective and anti-apoptotic effects. Further studies showed that bavachin increased Bcl-2 expression, while inhibited Bax expression, and also inhibited the decrease of mitochondrial membrane potential. As for the mechanism, the results displayed that bavachin upregulated Sirt1 and Nrf2 expression in vitro and in vivo, and inhibited the phosphorylation level of p65 in vivo. Taken as a conclusion, this study first provided evidence that bavachin inhibited neuronal damage caused by neuroinflammation and oxidative stress through the activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway, and bavachin might be a potential candidate for treating neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S1756464623002554BavachinNeuroinflammationSirt1Oxidative stress |
| spellingShingle | Xiao Zhang Yaping Guo Zhonghong Zhang Xintong Wu Li Li Zhiping Yang Zhipeng Li Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway Journal of Functional Foods Bavachin Neuroinflammation Sirt1 Oxidative stress |
| title | Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway |
| title_full | Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway |
| title_fullStr | Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway |
| title_full_unstemmed | Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway |
| title_short | Neuroprotective effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB pathway |
| title_sort | neuroprotective effects of bavachin against neuroinflammation and oxidative stress induced neuronal damage via activation of sirt1 nrf2 pathway and inhibition of nf κb pathway |
| topic | Bavachin Neuroinflammation Sirt1 Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002554 |
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