Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor
Introduction: Immunohistochemistry is a widely used diagnostic technique in pathology, the antibodies used for unvailing a tissue’s origin being made up of proteins, more specifically aminoacids. Malignant peripheral nerve sheath tumors have a distinct immunohistochemistry profile, with great emphas...
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Media Med Publicis
2021-03-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2021/03/Clinical-Histological-Immunohistochemical-12.pdf |
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| author | Laura REBEGEA Elena NICULET Mihaela CRAESCU Dorel FIRESCU Georgiana Bianca CONSTANTIN Mihaela DUMITRU Cristina SERBAN Raul MIHAILOV Mihaela LUNGU |
| author_facet | Laura REBEGEA Elena NICULET Mihaela CRAESCU Dorel FIRESCU Georgiana Bianca CONSTANTIN Mihaela DUMITRU Cristina SERBAN Raul MIHAILOV Mihaela LUNGU |
| author_sort | Laura REBEGEA |
| collection | DOAJ |
| description | Introduction: Immunohistochemistry is a widely used diagnostic technique in pathology, the antibodies used for unvailing a tissue’s origin being made up of proteins, more specifically aminoacids. Malignant peripheral nerve sheath tumors have a distinct immunohistochemistry profile, with great emphasis concerning those with rhabdomyoblastic differentiation being positive for S-100 protein, myogenin, vimentin, CD99, p63, GFAP, caldesmon, desmin, and p53 and Myo-D1 (the later two revealing the striated muscle differentiation). Materials and methods: A case study concerning a patient suffering from a moderately differentiated (G2) non-keratinizing squamous cell carcinoma of the lung highlighted the development of an undifferentiated sarcomatous proliferation on the left hemithorax, 7 years after the initial external radiotherapy treatment for the malignant lung tumor. Results: The immunohistochemistry analysis of the thoracic wall invasive tumor revealed it to be a malignant peripheal nerve sheath tumor with rhabdomyoblastic differentiation (Triton tumor) with the positivity for the specific aforementioned markers and a proliferation index – Ki67 of 90%. Chemotherapy was the elective treatment which was followed for 1 month, the patient having a rapid downward evolution towards exitus, with a 33 month post-diagnosis survival. Conclusions: This case was presented due to the rarity and difficulty of the diagnosis, consisting of a rare subtype of malignant peripheral nerve sheath tumor for which there is no therapeutic consensus and with an un-favorable prognosis. |
| first_indexed | 2024-12-19T00:44:59Z |
| format | Article |
| id | doaj.art-85efc9087e144200aefc7d4590b01fdb |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-12-19T00:44:59Z |
| publishDate | 2021-03-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-85efc9087e144200aefc7d4590b01fdb2022-12-21T20:44:18ZengMedia Med PublicisModern Medicine1223-04722360-24732021-03-012819397https://doi.org/10.31689/rmm.2021.28.1.93Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) TumorLaura REBEGEA0Elena NICULET1Mihaela CRAESCU2Dorel FIRESCU3Georgiana Bianca CONSTANTIN4Mihaela DUMITRU5Cristina SERBAN6Raul MIHAILOV7Mihaela LUNGU8Department of Radiotherapy, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaMedical Clinical Department, Faculty of Medicine and Pharmacy, „Dunarea de Jos” University, Galati, RomaniaDepartment of Radiotherapy, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaIInd Clinic of Surgery, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaIInd Clinic of Surgery, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaDepartment of Radiotherapy, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaIInd Clinic of Surgery, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaIInd Clinic of Surgery, „Sf. Apostol Andrei” Emergency Clinical Hospital, Galati, RomaniaMedical Clinical Department, Faculty of Medicine and Pharmacy, „Dunarea de Jos” University, Galati, RomaniaIntroduction: Immunohistochemistry is a widely used diagnostic technique in pathology, the antibodies used for unvailing a tissue’s origin being made up of proteins, more specifically aminoacids. Malignant peripheral nerve sheath tumors have a distinct immunohistochemistry profile, with great emphasis concerning those with rhabdomyoblastic differentiation being positive for S-100 protein, myogenin, vimentin, CD99, p63, GFAP, caldesmon, desmin, and p53 and Myo-D1 (the later two revealing the striated muscle differentiation). Materials and methods: A case study concerning a patient suffering from a moderately differentiated (G2) non-keratinizing squamous cell carcinoma of the lung highlighted the development of an undifferentiated sarcomatous proliferation on the left hemithorax, 7 years after the initial external radiotherapy treatment for the malignant lung tumor. Results: The immunohistochemistry analysis of the thoracic wall invasive tumor revealed it to be a malignant peripheal nerve sheath tumor with rhabdomyoblastic differentiation (Triton tumor) with the positivity for the specific aforementioned markers and a proliferation index – Ki67 of 90%. Chemotherapy was the elective treatment which was followed for 1 month, the patient having a rapid downward evolution towards exitus, with a 33 month post-diagnosis survival. Conclusions: This case was presented due to the rarity and difficulty of the diagnosis, consisting of a rare subtype of malignant peripheral nerve sheath tumor for which there is no therapeutic consensus and with an un-favorable prognosis.https://medicinamoderna.ro/wp-content/uploads/2021/03/Clinical-Histological-Immunohistochemical-12.pdfimmunohistochemistrymarker of proliferationtriton tumor |
| spellingShingle | Laura REBEGEA Elena NICULET Mihaela CRAESCU Dorel FIRESCU Georgiana Bianca CONSTANTIN Mihaela DUMITRU Cristina SERBAN Raul MIHAILOV Mihaela LUNGU Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor Modern Medicine immunohistochemistry marker of proliferation triton tumor |
| title | Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor |
| title_full | Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor |
| title_fullStr | Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor |
| title_full_unstemmed | Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor |
| title_short | Clinical, Histological, Immunohistochemical Aspects in a Rare Malignant Peripheral Nerve Sheath (Triton) Tumor |
| title_sort | clinical histological immunohistochemical aspects in a rare malignant peripheral nerve sheath triton tumor |
| topic | immunohistochemistry marker of proliferation triton tumor |
| url | https://medicinamoderna.ro/wp-content/uploads/2021/03/Clinical-Histological-Immunohistochemical-12.pdf |
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