Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway
β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), and orally administered BCP exhibits various bio...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222008125 |
| _version_ | 1811188103201685504 |
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| author | Chihiro Kishi Mayo Higashihara Yuki Takemoto Moeka Kamei Yuri Yoshioka Shinichi Matsumura Kazuya Yamada Takanori Kobayashi Yoshiharu Matahira Tatsuya Moriyama Nobuhiro Zaima |
| author_facet | Chihiro Kishi Mayo Higashihara Yuki Takemoto Moeka Kamei Yuri Yoshioka Shinichi Matsumura Kazuya Yamada Takanori Kobayashi Yoshiharu Matahira Tatsuya Moriyama Nobuhiro Zaima |
| author_sort | Chihiro Kishi |
| collection | DOAJ |
| description | β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), and orally administered BCP exhibits various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, it is still unclear how volatile BCP affects living organisms. We previously reported that inhaled BCP is transferred to sera and organs in mice; additionally, metabolomic analysis revealed inhaled BCP affect the dynamics of metabolites in the livers of mice. These data suggest that inhaled BCP may affect several biological activities by stimulating biological systems. In this study, we evaluated the effects of BCP inhalation on nicotine-induced degeneration of the aortic wall. In the group of mice which inhaled volatile BCP, nicotine-induced increases in elastic fiber degradation and matrix metalloproteinase-2 (MMP-2)-positive areas were attenuated. In addition, BCP improved the nicotine-induced stiffness of aortae and vulnerability to aortic rupture. In cultured aortae, the suppressive effects of BCP were inhibited by the CB2 receptor inhibitor AM630. These results suggest that inhaled BCP is incorporated into the aortic wall and prevents nicotine-induced degeneration of the aorta via a CB2 receptor-dependent pathway. |
| first_indexed | 2024-04-11T14:14:45Z |
| format | Article |
| id | doaj.art-85f04a984b7c434aa71e8cd2abb09932 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:14:45Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-85f04a984b7c434aa71e8cd2abb099322022-12-22T04:19:36ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113423Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathwayChihiro Kishi0Mayo Higashihara1Yuki Takemoto2Moeka Kamei3Yuri Yoshioka4Shinichi Matsumura5Kazuya Yamada6Takanori Kobayashi7Yoshiharu Matahira8Tatsuya Moriyama9Nobuhiro Zaima10Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, JapanGraduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, JapanGraduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, JapanGraduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, JapanINABATA KORYO, Co., Ltd., 3-5-20 Tagawa, Yodogawa, Osaka 532-0027, JapanINABATA KORYO, Co., Ltd., 3-5-20 Tagawa, Yodogawa, Osaka 532-0027, JapanSunsho Pharmaceutical Co., Ltd., 1468 Atsuhara, Fuji, Shizuoka 419-0201 JapanSunsho Pharmaceutical Co., Ltd., 1468 Atsuhara, Fuji, Shizuoka 419-0201 JapanSunsho Pharmaceutical Co., Ltd., 1468 Atsuhara, Fuji, Shizuoka 419-0201 JapanGraduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan; Agricultural Technology and Innovation Research Institute, Kindai University, Nara 631-8505, JapanGraduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan; Agricultural Technology and Innovation Research Institute, Kindai University, Nara 631-8505, Japan; Correspondence to: Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), and orally administered BCP exhibits various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, it is still unclear how volatile BCP affects living organisms. We previously reported that inhaled BCP is transferred to sera and organs in mice; additionally, metabolomic analysis revealed inhaled BCP affect the dynamics of metabolites in the livers of mice. These data suggest that inhaled BCP may affect several biological activities by stimulating biological systems. In this study, we evaluated the effects of BCP inhalation on nicotine-induced degeneration of the aortic wall. In the group of mice which inhaled volatile BCP, nicotine-induced increases in elastic fiber degradation and matrix metalloproteinase-2 (MMP-2)-positive areas were attenuated. In addition, BCP improved the nicotine-induced stiffness of aortae and vulnerability to aortic rupture. In cultured aortae, the suppressive effects of BCP were inhibited by the CB2 receptor inhibitor AM630. These results suggest that inhaled BCP is incorporated into the aortic wall and prevents nicotine-induced degeneration of the aorta via a CB2 receptor-dependent pathway.http://www.sciencedirect.com/science/article/pii/S0753332222008125β-caryophylleneNicotineVascular diseaseCB2 receptor |
| spellingShingle | Chihiro Kishi Mayo Higashihara Yuki Takemoto Moeka Kamei Yuri Yoshioka Shinichi Matsumura Kazuya Yamada Takanori Kobayashi Yoshiharu Matahira Tatsuya Moriyama Nobuhiro Zaima Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway Biomedicine & Pharmacotherapy β-caryophyllene Nicotine Vascular disease CB2 receptor |
| title | Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway |
| title_full | Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway |
| title_fullStr | Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway |
| title_full_unstemmed | Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway |
| title_short | Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway |
| title_sort | inhaled volatile β caryophyllene is incorporated into the aortic wall and attenuates nicotine induced aorta degeneration via a cb2 receptor dependent pathway |
| topic | β-caryophyllene Nicotine Vascular disease CB2 receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222008125 |
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