The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target
Galectin-3 is the most studied member of the Galectin family, with a large range of mediation in biological activities such as cell growth, proliferation, apoptosis, differentiation, cell adhesion, and tissue repair, as well as in pathological processes such as inflammation, tissue fibrosis, and ang...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15516 |
| _version_ | 1797631869855989760 |
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| author | Ziyi Zhou Zhaochen Feng Xiaojia Sun Yusheng Wang Guorui Dou |
| author_facet | Ziyi Zhou Zhaochen Feng Xiaojia Sun Yusheng Wang Guorui Dou |
| author_sort | Ziyi Zhou |
| collection | DOAJ |
| description | Galectin-3 is the most studied member of the Galectin family, with a large range of mediation in biological activities such as cell growth, proliferation, apoptosis, differentiation, cell adhesion, and tissue repair, as well as in pathological processes such as inflammation, tissue fibrosis, and angiogenesis. As is known to all, inflammation, aberrant cell apoptosis, and neovascularization are the main pathophysiological processes in retinal degeneration and many ocular diseases. Therefore, the review aims to conclude the role of Gal3 in the retinal degeneration of various diseases as well as the occurrence and development of the diseases and discuss its molecular mechanisms according to research in systemic diseases. At the same time, we summarized the predictive role of Gal3 as a biomarker and the clinical application of its inhibitors to discuss the possibility of Gal3 as a novel target for the treatment of ocular diseases. |
| first_indexed | 2024-03-11T11:29:51Z |
| format | Article |
| id | doaj.art-85f14c891d7c41ec86fa0df127b6f9ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:29:51Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-85f14c891d7c41ec86fa0df127b6f9ac2023-11-10T15:04:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211551610.3390/ijms242115516The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic TargetZiyi Zhou0Zhaochen Feng1Xiaojia Sun2Yusheng Wang3Guorui Dou4Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaGalectin-3 is the most studied member of the Galectin family, with a large range of mediation in biological activities such as cell growth, proliferation, apoptosis, differentiation, cell adhesion, and tissue repair, as well as in pathological processes such as inflammation, tissue fibrosis, and angiogenesis. As is known to all, inflammation, aberrant cell apoptosis, and neovascularization are the main pathophysiological processes in retinal degeneration and many ocular diseases. Therefore, the review aims to conclude the role of Gal3 in the retinal degeneration of various diseases as well as the occurrence and development of the diseases and discuss its molecular mechanisms according to research in systemic diseases. At the same time, we summarized the predictive role of Gal3 as a biomarker and the clinical application of its inhibitors to discuss the possibility of Gal3 as a novel target for the treatment of ocular diseases.https://www.mdpi.com/1422-0067/24/21/15516galectin-3retinal degenerationmolecular mechanismsdiagnosticsmolecular therapy |
| spellingShingle | Ziyi Zhou Zhaochen Feng Xiaojia Sun Yusheng Wang Guorui Dou The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target International Journal of Molecular Sciences galectin-3 retinal degeneration molecular mechanisms diagnostics molecular therapy |
| title | The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target |
| title_full | The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target |
| title_fullStr | The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target |
| title_full_unstemmed | The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target |
| title_short | The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target |
| title_sort | role of galectin 3 in retinal degeneration and other ocular diseases a potential novel biomarker and therapeutic target |
| topic | galectin-3 retinal degeneration molecular mechanisms diagnostics molecular therapy |
| url | https://www.mdpi.com/1422-0067/24/21/15516 |
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